Evidence map›Paper›PMID 41023924›Full record

ArticleBMC neurology2025

Lymphomatosis cerebri presenting with rapidly progressive parkinsonism and Holmes tremor: a case report.

Tsukika Iguchi, Tsuyoshi Furuya, Takahiro Koinuma, Asuka Nakajima, Atsuhito Fuse, Hiroto Eguchi, Yasunori Sugiyama, Yasushi Shimo

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tsukika IguchiDepartment of Neurology, Juntendo University Nerima Hospital, 3-1-10, Takanodai, Nerima, Tokyo, Japan.
Tsuyoshi FuruyaDepartment of Neurology, Juntendo University Nerima Hospital, 3-1-10, Takanodai, Nerima, Tokyo, Japan. t-furuya@juntendo.ac.jp.
Takahiro KoinumaDepartment of Neurology, Juntendo University Nerima Hospital, 3-1-10, Takanodai, Nerima, Tokyo, Japan.
Asuka NakajimaDepartment of Neurology, Juntendo University Nerima Hospital, 3-1-10, Takanodai, Nerima, Tokyo, Japan.
Atsuhito FuseDepartment of Neurology, Juntendo University Nerima Hospital, 3-1-10, Takanodai, Nerima, Tokyo, Japan.
Hiroto EguchiDepartment of Neurology, Juntendo University Nerima Hospital, 3-1-10, Takanodai, Nerima, Tokyo, Japan.
Yasunori SugiyamaDepartment of Neurosurgery, Juntendo University Nerima Hospital, Tokyo, Japan.
Yasushi ShimoDepartment of Neurology, Juntendo University Nerima Hospital, 3-1-10, Takanodai, Nerima, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLymphomatosis cerebri (LC) is a rare subtype of primary central nervous system lymphoma (PCNSL) characterized by diffuse infiltration without mass formation. LC typically presents with cognitive decline and gait disturbances; however, extrapyramidal manifestations, including Parkinsonism and Holmes tremor, are exceedingly rare. This report describes a unique case highlighting the diagnostic challenges and atypical manifestations of LC. CASE PRESENTATION: A 75-year-old man presented with rapidly progressive cognitive decline, Parkinsonism, and Holmes tremor. Brain magnetic resonance imaging (MRI) revealed diffuse T2 and FLAIR hyperintensities involving the deep white matter, basal ganglia, and midbrain, without contrast enhancement. Despite normal dopamine transporter imaging, biopsy confirmed diffuse large B-cell lymphoma, consistent with LC. The patient received whole-brain radiation therapy, resulting in mild improvement.

conclusionsThis case illustrates that LC can manifest with atypical parkinsonian syndromes, such as parkinsonism and Holmes tremor. Clinicians should consider LC in the differential diagnosis of rapidly progressive movement disorders, especially when neuroimaging reveals diffuse non-enhancing white matter lesions such as leukodystrophy and demyelinating disease. Advanced imaging modalities such as ASL-MRI may facilitate early diagnosis and biopsy targeting.

Indexed as

Brain NeoplasmsLymphoma, Large B-Cell, DiffuseParkinsonian DisordersTremorAgedDisease ProgressionHumansMagnetic Resonance ImagingMaleASL-MRICognitive impairmentDiffuse large B-cell lymphomaHolmes tremorLymphomatosis cerebriMovement disordersNeuro-oncologyParkinsonismPrimary central nervous system lymphoma

Identifiers

PMID41023924
PMCPMC12482555

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