SynthesisBMC pregnancy and childbirth2025
Epigenetic landscape of placental tissue in preeclampsia: a systematic review of DNA methylation profiles.
Synthesis in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epigenetic alterations in preeclampsia: a systematic review of current mechanisms and biomarker potential.Journal of medicine and life · 2026Pooled it
- Machine Learning and Functional Analysis of Placental DNA Methylation Signatures for Early-Onset Preeclampsia.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- MBD1-Mediated SDHD Methylation Aggravates Preeclampsia Progression via Triggering Mitochondrial Dysfunction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Placental molecular subtypes of severe preeclampsia reveal divergent aging trajectories and fetal growth outcomes.medRxiv : the preprint server for health sciences · 2026Article
- Epigenetic mechanisms in preeclampsia: translational therapeutic strategies and precision-medicine perspectives.Journal of medicine and life · 2026Review
- Epigenetic Regulation of Imprinted Genes in the Neurodevelopment of Offspring Born to Women with Preeclampsia: A Review.International journal of women's health · 2026Review
- Early non-invasive epigenetic approach for assessing trisomy risk in maternal plasma.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preeclampsia (PE) is a complex pregnancy disorder characterized by hypertension and organ dysfunction, significantly impacting maternal and fetal health. This systematic review investigates the epigenetic modifications, specifically DNA methylation patterns, in placental tissue from PE pregnancies. We conducted a comprehensive literature search across multiple databases including PubMed, Scopus, Web of Science, and Embase for studies published up to November 2024. The review analyzed genome-wide methylation studies and gene-specific methylation patterns in placental tissue, revealing significant differential methylation in numerous genes and pathways associated with PE pathogenesis. Our findings highlight distinct methylation profiles between early-onset and late-onset PE, tissue-specific methylation patterns within the placenta, and potential therapeutic and diagnostic implications. This review contributes to understanding the epigenetic mechanisms underlying PE and identifies promising biomarkers for early detection and intervention strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.