SynthesisBMC infectious diseases2025
Temporal and geographic trends in extended-spectrum cephalosporins resistance among Neisseria gonorrhoeae isolates worldwide: a systematic review and meta-analysis.
Synthesis in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- ProtPen combines sequence- and structure-based approaches to facilitate protein function predictions on a proteome-wide scale.bioRxiv : the preprint server for biology · 2026Article
- Global resistome architecture of Escherichia coli across human and animal hosts: analysis of 9,696 genome.BMC microbiology · 2026Article
- Socio-economic impact of antimicrobial resistance in Pakistan: a comprehensive review.Frontiers in public health · 2026Review
- First Study on Antimicrobial Susceptibility and Molecular Epidemiology ofInfection and drug resistance · 2026Article
- Whole genome sequencing of Neisseria gonorrhoeae among key populations in two cities of Bangladesh reveals genomic diversity and stable antimicrobial resistance.BMC infectious diseases · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The global emergence of antibiotic resistance in Neisseria gonorrhoeae (NG) infections poses a critical public health challenge. This study aimed to evaluate global resistance rates to extended-spectrum cephalosporins (ESCs) in N. gonorrhoeae, considering factors such as time, geography, antimicrobial susceptibility testing (AST), and resistance interpretation. A systematic review and meta-analysis (from 1988 to 2025) of 252 studies from 71 countries reported a weighted pooled resistance rate (WPR) of ≤ 2.5% for ESCs. Significant temporal variation in ESCs-resistant isolates (P < 0.05) underscores the dynamic nature of resistance development. Significantly, there was a difference in penicillin resistance rates between countries/ continents, and AST (P < 0.001). These findings emphasize the urgent need for effective antimicrobial stewardship, enhanced contact tracing, and comprehensive monitoring systems to combat antimicrobial resistance in gonococcal infections.
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