ArticleBMC medical imaging2025
Investigation of MRI features in subtypes of primary central nervous system diffuse large B-cell lymphoma.
Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Bilateral Upper Extremity Superficial Venous Thrombosis and Altered Mental Status as Initial Manifestations of Aggressive B-Cell Lymphoma: A Case Report.Clinical case reports · 2026Article
- Preoperative phenotypic stratification of primary central nervous system lymphoma using multiparametric MRI-based radiomics: prediction of germinal center B-cell-like and double-expression status.Frontiers in oncology · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
purposeThis study aims to investigate the clinical utility of multiparametric MRI features in distinguishing between germinal center B-cell-like (GCB) and non-germinal center B-cell-like (non-GCB) subtypes of primary central nervous system (CNS) diffuse large B-cell lymphoma (DLBCL), with the objective of establishing a non-invasive diagnostic protocol that could potentially reduce dependence on invasive histopathological confirmation.
methodsThis study retrospectively included 160 patients with primary CNS DLBCL (53 GCB subtype and 107 non-GCB subtype) confirmed by pathology at Huashan Hospital, Fudan University, from March 2013 to December 2024. All patients underwent multiparametric MRI scans, including T1WI, T2-FLAIR, DWI, and T1-CE. Three senior radiologists collected and assessed the clinical and imaging features of the patients, including: gender, age, number of lesions, location, ADC ratio, maximum diameter, minimum diameter, presence of cystic or necrotic changes, regularity of margins, “fist sign”, “horn sign”, “umbilication sign”, “butterfly sign”, meningeal involvement, ependymal involvement, degree of peritumoral edema, and mass effect. Statistical analyses were performed with SPSS 29.0. Continuous variables were compared using t-tests, and categorical/ordinal variables with χ² or Mann–Whitney U tests (significance set at P < 0.05). Area-under-the-curve (AUC) values were derived from non-parametric ROC analysis using the DeLong method.
resultsSignificant differences were observed in multiple MRI features between the GCB and non-GCB types of DLBCL. The non-GCB type was more likely to present as a solitary lesion (P = 0.006), had a higher incidence of cystic or necrotic changes (P = 0.013), irregular margins (P = 0.016), ependymal involvement (P = 0.046), and exhibited the “fist sign” (P = 0.034) and more severe peritumoral edema (P = 0.047).
conclusionsSignificant differences in MRI features exist between the GCB and non-GCB types of primary CNS DLBCL, providing a new approach for non-invasive subtyping of DLBCL in clinical practice.
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