ArticleBMC infectious diseases2025
Effect of biofire blood culture identification 2 (BCID2) panel versus a matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) rapid incubation protocol on time to optimal therapy in patients with positive blood cultures.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Beyond β-Lactams: Defining the Role of Eravacycline in Multidrug-Resistant and Metallo-β-Lactamase-Producing Infections.Antibiotics (Basel, Switzerland) · 2026Review
- Tri-layer microbiology for LMIC Hospitals: linking syndromic panels with reflex culture and targeted sequencing for real world care - a narrative review.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesReview
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Authors and funding
5 authors.
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Abstract
Rapid diagnostic technology (RDT) is a valuable tool that can be used to optimize antimicrobial therapy for patients with bloodstream infections. Several technologies for rapid organism identification exist including matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) and the BioFire® Blood Culture Identification 2 (BCID2) Panel. This multicenter, retrospective, cohort study compared results from patients with a positive blood culture, in which primary identification was performed via a rapid incubation MALDI-TOF protocol (Rapid MALDI-TOF MS) compared to the BCID2 molecular identification Panel. The primary outcome was time to optimal therapy (TTOT). A total of 221 patients were included (Rapid MALDI-TOF MS = 117; BCID2 Panel = 104). Utilization of the BCID2 Panel compared to Rapid MALDI-TOF MS significantly reduced overall TTOT (21.1 h vs. 41.1 h, p < 0.01). This significant reduction in TTOT with the BCID2 Panel was observed with gram-negative bacteremia (4 h vs. 37 h, p < 0.01) and gram-positive bacteremia (17.8 h vs. 41.1 h, p < 0.01), but was not statistically significant for blood cultures deemed contaminants (42 h vs. 43.5 h, p = 0.58). Time to effective therapy (TTET) was improved with the BCID2 Panel although not statistically significant (1.5 h vs. 7.5 h, p = 0.06). No differences were observed with hospital length of stay or clinical failure. Utilization of the BCID2 Panel significantly decreased time to optimal antimicrobial therapy compared to Rapid MALDI-TOF MS for patients with positive blood cultures.
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