ArticleBMC geriatrics2025
Mitigation of detraining effects: physical activity improves protein profile and physical function of aged amid COVID-19.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Pulsed Electromagnetic Field Therapy for Mild-to-Moderate Knee Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial.Journal of cachexia, sarcopenia and muscle · 2026Trial
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Authors and funding
17 authors.
Funding
Abstract
aimWe investigated the impact of abrupt interruption, imposed by COVID-19, and subsequent resumption of regular practice of a combined exercise training program on protein, renal profile, and physical functional capacity in physically active older adults before the pandemic.
methodsThirty-five volunteers (mean age 64.36 ± 19.43 years) participated, with data collected before the COVID-19 pandemic (PRE), 12 months after social isolation (PAN, detraining period), and 10 months after returning to regular exercise (POST).
resultsIn the POST period, both older women (n = 26) and men (n = 9) exhibited higher serum levels of albumin and total protein (p < 0.0001 for albumin and total proteins in older women group; p = 0.0033 for albumin and p = 0.0002 for total proteins in older men group) compared to PRE and PAN. Older women showed, both at PAN and POST, elevated serum creatinine levels (p = 0.0309; p = 0.0003, respectively) and Timed Up and Go Test (TUGT) values (p = 0.0096; p = 0.0013, respectively), along with decreased estimated creatinine clearance in PAN (p = 0.0132; p = 0.0005, respectively) compared to PRE. Additionally, older women demonstrated lower gait speed (p = 0.0210) and muscle strength (p = 0.0002) in POST compared to PAN and PRE. Older men exhibited higher serum creatinine levels and estimated creatinine clearance in POST compared to PRE. Significant correlations between biochemical parameters, estimated creatinine clearance, and physical functional tests were observed, particularly in older women.
conclusionsOverall, the study suggests that resuming combined exercise training partially mitigated the detraining-induced impairment in metabolic and physical capacities among older adults.
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