Evidence map›Paper›PMID 41023854›Full record

ArticleBMC gastroenterology2025

The role of serum trimethylamine n-oxide and lipopolysaccharide levels in the pathogenesis of chronic gastritis infected with Helicobacter pylori.

Ugur Kaplankaya, Erhan Onalan, Tugce Kaymaz, Burkay Yakar, Ruveyda Atilla, Aykut Bulu, Senanur Onalan Yıldırım, Mehmet Ferit Gursu, Emir Donder, Mustafa Hayırlıdağ

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In one paragraph

Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Ugur KaplankayaDepartment of Internal Medicine, Fethi Sekin City Hospital, Elazig, Turkey.ORCID http://orcid.org/0009-0001-8529-9501
Erhan OnalanMedical School, Department of Internal Medicine, Firat University, Elazig, 23119, Turkey.ORCID http://orcid.org/0000-0001-5395-0390
Tugce KaymazFaculty of Arts and Sciences, Department of Molecular Biology and Genetics, Nevsehir Hacı Bektas Veli University, Nevsehir, 50100, Turkey.ORCID http://orcid.org/0000-0002-1359-7358
Burkay YakarMedical School, Department of Family Medicine, Firat University, Elazig, 23119, Turkey. byakar@firat.edu.tr.ORCID http://orcid.org/0000-0003-2745-6561
Ruveyda AtillaDepartment of Internal Medicine, Cankırı State Hospital, Cankırı, 18000, Turkey.ORCID http://orcid.org/0000-0002-7516-3328
Aykut BuluDepartment of Internal Medicine, Fethi Sekin City Hospital, Elazig, Turkey.ORCID http://orcid.org/0000-0002-5792-3557
Senanur Onalan YıldırımDepartment of Emergency, Elazıg Medikal Hospital, Elazig, Turkey.ORCID http://orcid.org/0009-0003-2537-8894
Mehmet Ferit GursuMedical School, Department of Biochemıstry, Firat University, Elazig, 23119, Turkey.ORCID http://orcid.org/0000-0003-3552-7315
Emir DonderMedical School, Department of Internal Medicine, Firat University, Elazig, 23119, Turkey.ORCID http://orcid.org/0000-0003-2537-6023
Mustafa HayırlıdağMedical School, Department of Medical History and Ethics, Firat University, Elazig, 23119, Turkey.ORCID http://orcid.org/0000-0002-4686-5101

Funding

Fırat University Scientific Research Project Unit. (project number: TF:24.03) TF:24.03)
6 · The paper itself

Abstract

backgroundHelicobacter pylori (HP) infection can cause chronic, intense inflammation of the gastric mucosa, which can lead to stomach cancer. Trimethylamine N-oxide (TMAO) is a dietary metabolite that increases HP virulence and inflammatory process. In this study, we aimed to find out how serum TMAO, lipopolysaccharide (LPS) and pepsinogen levels are affected in patients with HP-induced chronic gastritis.

methodsForty-five age- and sex-matched patients diagnosed with chronic gastritis caused by H. Pylori and 45 healthy controls were included in this cross-sectional study. The diagnosis of H. Pylori-associated chronic gastritis was confirmed by endoscopy and biopsy. Serum TMAO, LPS, pepsinogen 1 and pepsinogen 2 levels were studied by the ELISA method.

resultsSerum TMAO level of patients with HP gastritis was 48.61 (2.29-120.66) and that of the control group was 7.89 (1.22-76.40). Serum TMAO levels were statistically significantly higher in patients with HP-related chronic gastritis than in the control group (p < 0.001). Serum LPS levels were statistically significantly higher in patients with HP-related chronic gastritis than in the control group (p = 0.008). Serum pepsinogen 1 levels were statistically significantly higher in patients with HP-related chronic gastritis than in the control group (p = 0.001).

conclusionThe present study found elevated serum TMAO, LPS and pepsinogen 1 levels in patients with H. Pylori gastritis. These serum markers can be used as a non-invasive method in the evaluation of chronic gastritis infected with H. pylori.

Indexed as

GastritisHelicobacter InfectionsHelicobacter pyloriLipopolysaccharidesMethylaminesAdultAgedBiomarkersCase-Control StudiesChronic DiseaseCross-Sectional StudiesFemaleHumansMaleMiddle AgedPepsinogen ABiomarkersLipopolysaccharidesMethylaminesPepsinogen APepsinogen CtrimethyloxamineChronic gastritisHelicobacter pyloriLipopolysaccharideTrımethylamıne n-oxıde

Identifiers

PMID41023854
PMCPMC12482537

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.