Evidence map›Paper›PMID 41023824›Full record

ArticleBMC genomics2025

The MeaB bZIP transcription factor is needed for proper nitrosative stress response induced by nitrite in Aspergillus fumigatus.

Kinga Edina Varga, Zsigmond Benkő, Károly Antal, Kitti Pázmándi, Zoltán Palczert, István Pócsi, Tamás Emri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kinga Edina VargaDepartment of Molecular Biotechnology and Microbiology, Institute of Biotechnology, Faculty of Science and Technology, University of Debrecen, Debrecen, H-4032, Hungary.
Zsigmond BenkőDepartment of Molecular Biotechnology and Microbiology, Institute of Biotechnology, Faculty of Science and Technology, University of Debrecen, Debrecen, H-4032, Hungary.
Károly AntalDepartment of Zoology, Eszterházy Károly Catholic University, Eger, H-3300, Hungary.
Kitti PázmándiDepartment of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.
Zoltán PalczertDepartment of Molecular Biotechnology and Microbiology, Institute of Biotechnology, Faculty of Science and Technology, University of Debrecen, Debrecen, H-4032, Hungary.
István PócsiDepartment of Molecular Biotechnology and Microbiology, Institute of Biotechnology, Faculty of Science and Technology, University of Debrecen, Debrecen, H-4032, Hungary.
Tamás EmriDepartment of Molecular Biotechnology and Microbiology, Institute of Biotechnology, Faculty of Science and Technology, University of Debrecen, Debrecen, H-4032, Hungary. emri.tamas@science.unideb.hu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMeaB is a bZIP-type transcription factor in fungi. This protein is known to regulate nitrogen metabolism, contribute to nitrite susceptibility and determine virulence in aspergilli. We hypothesized that MeaB is required for proper nitric oxide (NO) metabolism of fungi. Here, we tested this hypothesis on the human pathogenic fungus Aspergillus fumigatus using a transcriptomics approach.

resultsDeletion of the meaB gene increased nitrite, diethylamine NONOate and menadione-sodium bisulfite stress sensitivity, but not that of terc-butyl hydroperoxide or H

conclusionsTranscriptomic data implies that MeaB affected fine-tuned regulation of arginine metabolism genes, and the alteration in arginine dependent processes (including siderophore production and possibly NO homeostasis) was responsible for the altered phenotype of the ΔmeaB mutant. Our results also suggest that, although inhibition of A. fumigatus defense against nitrosative stress may not be an effective antifungal therapy for all A. fumigatus strains, a combined approach based on disruption of both iron and NO homeostasis is promising.

Indexed as

Aspergillus fumigatusBasic-Leucine Zipper Transcription FactorsFungal ProteinsNitritesNitrosative StressGene Expression ProfilingGene Expression Regulation, FungalHumansNitric OxideBasic-Leucine Zipper Transcription FactorsFungal ProteinsNitric OxideNitritesAspergillus fumigatusIron homeostasisMeaB transcription factorNitrosative stressRNA sequencing

Identifiers

PMID41023824
PMCPMC12482460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.