Evidence map›Paper›PMID 41023769›Full record

ArticleEuropean journal of medical research2025

EMSY enhances glycolysis in ovarian cancer cells.

Shaosheng Wang, Na Xie, Ping Zha, Yingming Li, Minghui Wei, Ji Bai, Xiaohong Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shaosheng WangBlood Transfusion Department, Haikou People's Hospital, Haikou, 570208, Hainan, China.
Na XieDepartment of Pathology, The affiliated hospital of Hainan Medical University, Haikou, 571101, Hainan, China.
Ping ZhaWomen Health Care Department, Hainan Women and Children Medical Center, Haikou, 570312, Hainan, China.
Yingming LiBlood Transfusion Department, Haikou People's Hospital, Haikou, 570208, Hainan, China.
Minghui WeiBlood Transfusion Department, Haikou People's Hospital, Haikou, 570208, Hainan, China.
Ji BaiBlood Transfusion Department, Haikou People's Hospital, Haikou, 570208, Hainan, China.
Xiaohong ZhaoWomen Health Care Department, Hainan Women and Children Medical Center, Haikou, 570312, Hainan, China. zhaoxiaohx@hainmc.edu.cn.

Funding

the Natural Science Foundation of Hainan Province 823MS153
6 · The paper itself

Abstract

EMSY is critical in the progression of ovarian cancer; nevertheless, its impact on tumor metabolism is not widely known. This study showed ovarian cancer cells overexpressing EMSY produce more lactate and have upregulated LDHA expression; the promoting effect of EMSY on the malignant phenotype of these cells is eliminated when LDHA expression is knocked down or glycolysis is inhibited in ovarian cancer cells. Mechanistic studies revealed that EMSY interacts with β-catenin, and the knockdown of EMSY inhibits the transcriptional activation of LDHA by β-catenin. In summary, this study identifies EMSY's metabolic regulatory role in ovarian cancer cells and offers treatment of ovarian cancer with a new therapeutic target.

Indexed as

GlycolysisNeoplasm ProteinsOvarian NeoplasmsThyroid Hormonesbeta CateninCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansL-Lactate DehydrogenaseThyroid Hormone-Binding ProteinsWAP Four-Disulfide Core Domain Protein 2beta CateninLDHA protein, humanL-Lactate DehydrogenaseNeoplasm ProteinsThyroid Hormone-Binding ProteinsThyroid HormonesWAP Four-Disulfide Core Domain Protein 2WFDC2 protein, humanEMSYLDHAOvarian cancerβ-catenin

Identifiers

PMID41023769
PMCPMC12482080

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.