ArticleStem cell research & therapy2025
Cochlear-bioelectrode: Auditory response to cochlear implant can be improved by stem cell delivery into inner ear in a pig model.
Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Biohybrid cochlear implants: neural interfaces, regenerative pathways, and translational benchmarks.Journal of neuroengineering and rehabilitation · 2026Review
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Authors and funding
10 authors.
Funding
Abstract
backgroundThe cochlear implant (CI) is the most successful neural prosthesis and has improved the quality of life for over one million people with profound hearing loss. The number and function of spiral ganglion neurons (SGNs) in the cochlea are crucial to CI performance. Clinically, patients with significant SGN degeneration fail to return to normal life due to unsatisfactory performance of their CIs. This study aims to explore the efficacy of improve auditory function by delivering stem cells into the SGN region using a customized CI (defined as Cochlear-Bioelectrode).
methodsHuman induced pluripotent stem cells (hiPSCs) with a green fluorescent protein (GFP) marker were delivered cross the osseous spiral lamina via naturally existing openings and congregate in the SGN region by Cochlear-Bioelectrode after Cochlear implantation, electrically evoked auditory brainstem responses (EABR) were compared between those with and without stem cells delivery.
resultsIn seven days, efficient hiPSC migration into the SGN region was demonstrated with concurrent electric stimulation and stem cell delivery, while hipsc did not migrate into the sgn region with stem cell delivery alone. After two weeks of combined electric stimulation and stem cell delivery treatment, the number of SGNs increased significantly in the 60-day old pig model (mean number = 129.6 ± 1.61/field), compared to untreated deafness pigs of the same age (mean number = 6.2 ± 0.92/field). With the replenished SGNs, CI stimulation thresholds were significantly reduced and hearing sensitivity and dynamic range extended, as demonstrated by electrically evoked auditory brainstem responses.
conclusionsOur results showed that in vivo concurrent cochlear implant stimulation and hipsc delivery increased stem cells in the sgn region and lowered ci stimulation thresholds, paving the way to broad and promising clinical applications.
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