Evidence map›Paper›PMID 41023749›Full record

ReviewStem cell research & therapy2025

Head and neck cancer organoids: a panoramic perspective from basic construction to clinical translation.

Ruoyu Meng, Lianpin Yu, Xiaomei Li, Na Ning, Haibin Hao, Xiaonan Zhang, Jiabing Kong, Wei Song, Xinyu Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruoyu Meng *Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, People's Republic of China.
Lianpin Yu *Oral and Maxillofacial Surgery Department, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, People's Republic of China.
Xiaomei Li *Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, People's Republic of China.
Na NingShandong Fuwei Biotechnology Corporation, Jinan, 250021, Shandong, People's Republic of China.
Haibin HaoDepartment of Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, People's Republic of China.
Xiaonan ZhangShandong First Medical University (Shandong Academy of Medical Sciences), Jinan, 250021, Shandong, People's Republic of China.
Jiabing KongShandong First Medical University (Shandong Academy of Medical Sciences), Jinan, 250021, Shandong, People's Republic of China.
Wei SongDepartment of Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, People's Republic of China. songwei@sdfmu.edu.cn.
Xinyu LiDepartment of Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, People's Republic of China. lixinyu@sdfmu.edu.cn.ORCID http://orcid.org/0009-0001-8840-5533

Funding

Key R&D Plan of Shandong Province (Major Science and Technology Innovation Project) 2022CXGC020501Key R&D Plan of Shandong Province (Major Science and Technology Innovation Project) 2024CXGC010611Shandong Provincial Natural Science Foundation ZR2023QH405
6 · The paper itself

Abstract

Head and neck cancer (HNC), which refers to a heterogeneous group of malignancies, is a serious threat to human health. Its pathogenesis is complex, and the treatment faces many challenges. As an emerging in vitro three-dimensional (3D) model in recent years, organoids can highly mimic the structure and function of the source organs, which show unique advantages in the study of HNC. Patient-derived tumor organoids (PDTOs) can not only be used to explore the mechanism of tumor occurrence and development, but also provide a personalized drug sensitivity detection platform for precision medicine. Herein, we review the construction and application of HNC organoids and organoids-on-chips, discuss the advancement and effectiveness of this technology, the shortcomings and development direction of existing technologies in HNC field, hoping to provide reference for its further research and clinical transformation, and looking forward to its broad prospects in overcoming the difficult problems of HNC.

Indexed as

Head and Neck NeoplasmsOrganoidsHumansPrecision MedicineTranslational Research, BiomedicalHead and neck cancerOrganoid-on-a-chipOrganoidsPrecision medicine

Identifiers

PMID41023749
PMCPMC12481855

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.