Evidence map›Paper›PMID 41023718›Full record

ArticleEuropean journal of medical research2025

Brain structural alterations correlate with motor dysfunction in children with spastic cerebral palsy: a quantitative MRI study.

Qiang Wang, Jiale Zhang, Xiang Ren, Qijia Zhan, Wenbin Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qiang WangCollege of Computer and Network Engineering, Shanxi Datong University, Datong, China.
Jiale ZhangCollege of Computer and Network Engineering, Shanxi Datong University, Datong, China.
Xiang RenDepartment of Radiology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Qijia ZhanDepartment of Neurosurgery, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 355, Luding Rd., Putuo District, Shanghai, China.
Wenbin JiangDepartment of Neurosurgery, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 355, Luding Rd., Putuo District, Shanghai, China. m13524123022@163.com.

Funding

Fundamental Research Funds for the Central University YG2025QNA10Shanghai Public Health Research Special Program 2024GKQ33
6 · The paper itself

Abstract

backgroundSpastic cerebral palsy (CP) is a common cause of motor disability in children which caused by non-progressive brain injury. This study aimed to investigate the correlation between quantitative brain MRI parameters and motor dysfunction in children with spastic CP.

methods91 children with spastic CP and 91 controls were recruited. Brain volumes were measured using high-resolution T1-weighted Magnetic resonance imaging (MRI). Gross motor function was assessed using Gross Motor Function Measure-66 score (GMFM-66) and the muscle tone was evaluated by modified Ashworth scale and scored by modified Ashworth scale score.

resultsChildren with spastic CP showed significantly reduced total brain volume, white matter volume, gray matter volume, and white matter/total brain volume ratio compared to controls. In children with spastic CP, white matter volume and white matter/total brain volume ratio positively correlated with GMFM-66 scores (r = 0.56, p < 0.001; r = 0.47, p < 0.001). The muscle tone of specific muscles negatively correlated with brain volumes.

conclusionsWhite matter volumes are closely related to motor dysfunction in children with spastic CP. Quantitative MRI may serve as objective biomarkers for evaluating the severity and prognosis of spastic CP, providing basis for individualized rehabilitation strategies.

Indexed as

BrainCerebral PalsyMagnetic Resonance ImagingAdolescentCase-Control StudiesChildChild, PreschoolFemaleGray MatterHumansMaleWhite MatterCerebral palsyMagnetic resonance imagingMotor functionWhite matter

Identifiers

PMID41023718
PMCPMC12482735

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.