Wilson's disease with psychiatric symptoms: a case report.

Nguyen Van Tuan, Tran Nguyen Ngoc, Nguyen Thuy Hang, Tran My Ha

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Article in Journal of medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Nguyen Van TuanDepartment of Psychiatry, Hanoi Medical University, Hanoi Medical University, No. 1 Ton That Tung Str., Hanoi, 100000, Vietnam.

Tran Nguyen NgocDepartment of Psychiatry, Hanoi Medical University, Hanoi Medical University, No. 1 Ton That Tung Str., Hanoi, 100000, Vietnam. trannguyenngoc@hmu.edu.vn.ORCID http://orcid.org/0000-0002-9183-4486

Nguyen Thuy HangDepartment of Psychiatry, Hanoi Medical University, Hanoi Medical University, No. 1 Ton That Tung Str., Hanoi, 100000, Vietnam.

Tran My HaDepartment of Psychiatry, Hanoi Medical University, Hanoi Medical University, No. 1 Ton That Tung Str., Hanoi, 100000, Vietnam.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWilson's disease is a copper metabolic disorder defined by the body's accumulation of copper, which inhibits its excretion and initially manifests as liver and neurological symptoms. The patient reported herein showed only psychiatric symptoms and was diagnosed in the latter stages without typical Wilson's disease symptoms. The case underscores the complexity of diagnosing Wilson's disease, emphasizing the significant challenges regarding early detection and treatment efficacy. CASE PRESENTATION: We report the case of a 20-year-old Vietnamese male with Wilson's disease. The initial manifestations in the patient reported herein include psychiatric symptoms such as mood fluctuations, anger, irritation, impulsivity, emotional eruptions, weariness, and sleep disorders. The patient exhibited no symptoms of Wilson's disease as documented and was diagnosed solely via DNA sequencing, resulting in serious complications and an unfavorable prognosis.

conclusionsThis case underscores the complexity of Wilson's disease symptoms. Early identification and effective therapy are crucial for enhancing patient outcomes.

Indexed as

Hepatolenticular DegenerationCopperHumansMaleSleep Wake DisordersYoung AdultCopperATP7B mutationCase reportPsychiatric symptomsWilson’s disease

Identifiers

PMID41023711

DOI10.1186/s13256-025-05486-7

PMCPMC12482876

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LicenceCC BY-NC-ND

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