Trial reportJournal of neuroengineering and rehabilitation2025
Effects of 10-Hz rTMS over the leg motor cortex using a double-cone coil on lower limb motor recovery in subacute stroke: a randomised, double-blind, sham-controlled study.
Trial report in Journal of neuroengineering and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The trial behind it
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Who cites it
3 citing papers in PubMed.
- [Optimized decomposition of dynamic electroencephalography-functional near infrared spectroscopy brain functional networks for the analysis of repetitive transcranial magnetic stimulation combined with motor training].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Recent research on rehabilitation interventions for post-stroke gait and balance in low- and middle-income countries: a scoping review.BMC health services research · 2026Article
- Efficacy of repetitive transcranial magnetic stimulation on postoperative pain in patients undergoing video-assisted thoracoscopic surgery: study protocol for a prospective, single-center, randomized controlled trial.Frontiers in medicine · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundLower limb dysfunction following stroke poses important challenges to patients' mobility and quality of life. Repetitive transcranial magnetic stimulation (rTMS) using double-cone coils for deep stimulation offers a promising avenue for the improved motor recovery of these patients. However, the efficacy and safety of this approach remain underexplored.
methodsA total of 56 subacute stroke patients were randomised to rTMS or sham stimulation (n = 28 per group), over 15 sessions in 3 weeks. The primary outcome was that of Fugl-Meyer assessment of the lower extremity (FMA-LE) at T3, with secondary outcomes, including those of Berg Balance Scale (BBS), modified Barthel index (MBI) and Brunnstrom scale. TecnoBody balance equipment was used to quantify sway length (SL) and sway area (SA). All outcome assessments were performed at baseline (T0), after 1 week (T1), after 2 weeks (T2) and 3 weeks (T3) of intervention. Intention-to-treat and per-protocol analyses were performed.
resultsAmong the 212 inpatients screened, 56 patients (age, 61.50 ± 5.41 years; 17 women, 46 ischemic) were enrolled in the study. Significant group-by-time interactions occurred, with the rTMS group displaying greater improvements than the sham group in FMA-LE (F = 2.883, P = 0.038) and BBS (F = 3.379, P = 0.020). No significant interactions were observed for MBI (F = 2.245, P = 0.085) or Brunnstrom scale (F = 1.565, P = 0.200). At T3, the rTMS group showed a 1.5 point significantly higher FMA-LE scores (95% confidence interval: 0.567-2.433, P = 0.002) compared with the sham group. TecnoBody balance assessments also showed superior results of the rTMS group for SA (F = 6.902, P < 0.001) and SL (F = 6.837, P < 0.001).
conclusionsApplication of 10 Hz rTMS over the leg motor cortex with a double-cone coil holds potential to improve lower-limb motor function in subacute stroke patients.
trial registrationThis trial was registered under ClinicalTrials.gov ID No. ChiCTR2100051566, prospectively registered, on September 26, 2021.
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