Evidence map›Paper›PMID 41023683›Full record

SynthesisBMC infectious diseases2025

Cytomegalovirus infection contributes to acute rejection in solid organ transplant recipients: a systematic review and meta-analysis.

Amirreza Keyvanfar, Shabnam Tehrani, Mahdi Falah Tafti, Niki Talebian, Zahra Mohammadi, Mahsa Hojabri, Sepehr Ramezani, Mehrdad Yasaei, Setareh Khorrami, Shiva Nezami and 4 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Amirreza KeyvanfarInfectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. amirrezakeyvanfar@yahoo.com.
Shabnam TehraniInfectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Tehrani.shabnam89@yahoo.com.
Mahdi Falah TaftiStudent Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Niki TalebianStudent Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Zahra MohammadiSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mahsa HojabriInstitute of Human Virology, School of Medicine, University of Maryland, Baltimore, MD, USA.
Sepehr RamezaniSchool of Medicine, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
Mehrdad YasaeiDepartment of Pediatric Endocrinology and Metabolism, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Setareh KhorramiSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shiva NezamiInfectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Negar GhaediBasir Eye Health Research Center, Iran University of Medical Sciences, Tehran, Iran.
Davood YadegaryniaInfectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Elahe EghbalInfectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hanieh NajafiarabPreventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. haniye.najafiarab@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSolid organ transplant (SOT) recipients receive immunosuppressive drugs that predispose them to opportunistic infections, including cytomegalovirus (CMV) infection. In these patients, CMV infection can lead to life-threatening consequences, such as transplant rejection. This systematic review and meta-analysis investigated the role of CMV infection in the development of acute rejection in SOT recipients.

methodsPubMed, Embase, Scopus, and Web of Science databases were systematically searched for eligible publications until Jan 31, 2025. English-language studies reporting the association between CMV infection and acute rejection in adult SOT recipients were included. Baseline characteristics, transplanted organs, and CMV infection and acute rejection status in SOT recipients were independently extracted by two reviewers. The pooled odds ratio (ORs) with a 95% confidence interval (CI) was calculated using the random effect model.

resultsOverall, 27 studies with 6308 SOT recipients entered the meta-analysis. Acute rejection was significantly higher in SOT recipients with CMV infection than those without CMV infection (OR = 2.02, 95%CI 1.64-2.49, I

conclusionsCMV infection approximately doubles the risk of acute rejection in SOT recipients. This association differs between various organs, with liver transplants indicating the highest risk, followed by kidney and lung transplants.

Indexed as

Cytomegalovirus InfectionsGraft RejectionOrgan TransplantationTransplant RecipientsAdultCytomegalovirusHumansImmunosuppressive AgentsRisk FactorsImmunosuppressive AgentsCytomegalovirusGraft rejectionOpportunistic infectionsOrgan transplantation

Identifiers

PMID41023683
PMCPMC12482134

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.