ArticleBMC oral health2025
Evaluation of the effect of melatonin and ascorbic acid on bone healing in a rat model of osteoradionecrosis induced by tooth extraction.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundRadiotherapy applied in the treatment of head and neck cancers significantly increases the risk of developing osteoradionecrosis (ORN). As there is no universally accepted standard treatment protocol for ORN, evaluating the potential therapeutic effects of antioxidant agents such as melatonin and ascorbic acid is of great importance. This study aimed to investigate the effects of these agents on bone healing in an experimental ORN model through histopathological and immunohistochemical analyses.
methodsA total of 41 young-adult male Wistar-Albino rats were included in the study. All rats in the experimental groups received a single 20 Gy dose of radiotherapy, followed by tooth extraction seven days later. Group G3 received 20 mg/kg of melatonin intraperitoneally for 21 days post-RT and tooth extraction. Group G4 received 100 mg/kg of ascorbic acid intraperitoneally for 21 days. Group G5 received a combination of melatonin and ascorbic acid (20 mg/kg + 100 mg/kg) for the same duration. Immunohistochemical analyses were performed to evaluate bone healing, focusing on the expression of Bone Morphogenetic Protein-2 (BMP-2), Alkaline Phosphatase (ALP), Osteonectin (ONC), and Tartrate-Resistant Acid Phosphatase (TRAP).
resultsALP expression was significantly lower in the G2 group compared to both G1 and G5 (p < 0.05), although the difference was not significant when compared with G3 and G4. BMP-2 expression was significantly reduced in G2 compared to G1 (p < 0.05), but the differences between G2 and G3, G4, G5 were not statistically significant. ONC expression was significantly lower in G2 compared to G1 and G5 (p < 0.05), but not significantly different from G3 and G4. TRAP expression was higher in G2 than all other groups, though this difference did not reach statistical significance.
conclusionsThe findings indicate that melatonin and ascorbic acid may exert protective effects against ORN by enhancing bone healing.
trial registrationClinical trial number: not applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.