ArticleLipids in health and disease2025
Association between visceral lipid accumulation indicator and preserved ratio impaired spirometry in US adults: a population-based study from 2007 to 2012.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The Inflammation-Metabolism Axis in Preserved Ratio Impaired Spirometry: Pathogenic Mechanisms and Translational Implications.Journal of inflammation research · 2026Review
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5 authors.
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Abstract
backgroundPreserved Ratio Impaired Spirometry (PRISm) is a condition characterized by a forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) ratio ≥ 0.70, yet FEV1 is below 80% of the predicted value. Recent studies suggest that visceral lipid accumulation may play a role in respiratory health, but the relationship between visceral fat indices and PRISm remains under explored. To investigate the relationship between indicators of visceral lipid accumulation and PRISm in US adults using data from the National Health and Nutrition Examination Survey (NHANES).
methodsData from three consecutive cycles of NHANES (2007-2012) were analyzed. Logistic regression and generalized additive models (GAM) were used to assess the relationship between various indices of visceral lipid accumulation and PRISm. The data was randomly divided into training (70%) and validation (30%) sets. Least Absolute Shrinkage and Selection Operator (LASSO) regression identified key factors for a nomogram model, which was evaluated using receiver operating characteristic(ROC) curves.
resultsA significant positive association was found between visceral fat indices and PRISm risk (P < 0.05). GAM analysis revealed a nonlinear relationship, with PRISm risk initially plateauing or slightly decreasing at lower levels of visceral fat indices before rising above a certain threshold (P for non-linearity < 0.05). The nomogram model demonstrated fair discriminative ability, with the area under the ROC curve (AUC) of 0.785 (95%CI: 0.771-0.800) in the training set and 0.769 (95%CI: 0.747-0.791) in the validation set.
conclusionsThis study establishes a robust association between visceral fat indicators and PRISm, highlighting the significance of lipid indices in evaluating respiratory health. Clinical screening for visceral fat indicators could be essential for more precise clinical interventions.
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