ArticleBMC gastroenterology2025
Relationship between the degree of Helicobacter pylori infection and miR-155 and miR-543 expression levels in gastric cancer.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo analyze the relationship between Helicobacter pylori (HP) infection degree and miR-155 and miR-543 expression levels in gastric cancer (GC).
methodsGC patients were retrospectively enrolled (n = 405), with their baseline data, 2-year follow-up records, and prognosis collected and analyzed. miR-155 and miR-543 expression levels in GC tissues were first predicted online and then determined in GC patient tissues using RT-qPCR. The correlations between miR-155 and miR-543 expression patterns and the U value of HP infection were analyzed through Spearman coefficient. A multivariate Cox regression model was established to analyze the risk factors for 2-year postoperative death of HP-positive GC patients. Kaplan-Meier curves were plotted to analyze the impact of miR-155 and miR-543 on the 2-year prognosis of HP-positive GC patients.
resultsmiR-155 and miR-543 were upregulated in GC tissues and cells, with significantly higher expression levels in HP-positive compared to HP-negative patients. miR-155 and miR-543 expression changes were correlated with the HP infection degree. There were significant differences in miR-155 and miR-543 expression patterns across tumor diameter, TNM staging, and lymph node metastasis degree. Upregulated miR-155 and miR-543, TNM stage III, and lymph node metastasis were independent risk factors for 2-year postoperative death in HP-positive GC patients. Upregulated miR-155 and miR-543 increased the 2-year postoperative death rate.
conclusionmiR-155 and miR-543 were upregulated in HP-positive GC patients, and their expression changes were correlated with HP infection degree. High miR-155 and miR-543 expression increased the risk of 2-year postoperative death in HP-positive GC patients.
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