Trial reportBMC anesthesiology2025
Addition of sufentanil to fospropofol disodium during induction of general anesthesia shortens time to sedation onset in elderly patients: a randomized controlled trial.
Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
backgroundFospropofol disodium is a water-soluble prodrug of propofol, with a significantly longer time to sedation than propofol. This prospective randomized controlled study aimed to evaluate the effect of adding sufentanil to fospropofol disodium during induction of general anesthesia on sedation quality in elderly patients.
methodsOne hundred and fifty elderly patients scheduled for elective surgery under general anesthesia were randomly assigned 1:1 to receive either fospropofol disodium (F group) or sufentanil combined with fospropofol disodium (S + F group) (n = 75 each). Patients randomized to F group received fospropofol disodium 10-15 mg/kg within 1 min for anesthesia induction. Patients randomized to S + F group received sufentanil 0.2-0.4 µg/kg, followed by fospropofol disodium within 1 min. The primary outcome was time to loss of consciousness, defined as the time to a Modified Observer's Assessment of Alertness/Sedation (MOAA/S) score of 1 after administration of fospropofol disodium. Secondary outcomes included sedation success rate and hemodynamic parameters. Safety outcomes included the incidence of adverse reactions such as injection pain, pruritus, and paresthesia.
resultsCompared to the F group, the S + F group had a significantly shorter time to loss of consciousness (91.00 [70.00, 112.00] s vs. 142.50 [121.00, 192.25] s, P < 0.001) and a higher sedation success rate (100% [75/75] vs. 90.7% [68/75], P = 0.020). The incidence of pruritus and paresthesia was significantly lower in the S + F group than in the F group (P < 0.05).
conclusionIn elderly patients undergoing general anesthesia, the combination of sufentanil and fospropofol disodium significantly shortened the time to loss of consciousness, improved sedation success and reduced the incidence of adverse reactions compared with fospropofol disodium alone.
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