Evidence map›Paper›PMID 41023519›Full record

ArticleInternational journal of clinical oncology2025

Lymph node metastasis risk in submucosal invasive gastric cancer based on C-reactive protein gene polymorphism analysis.

Kotaro Honda, Kohei Taniguchi, Kazumasa Komura, Tomohito Tanaka, Hidero Yoshimoto, Kentaro Matsuo, Yoshiro Imai, Ryo Tanaka, Mitsuaki Ishida, Yoshinobu Hirose and 2 more

Abstract read
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Article in International journal of clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kotaro HondaDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki, Osaka, 569-8686, Japan.
Kohei TaniguchiCenter for Medical Research & Development, Division of Translational Research, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki, Osaka, 569-8686, Japan. kohei.taniguchi@ompu.ac.jp.ORCID http://orcid.org/0000-0003-0648-1370
Kazumasa KomuraDepartment of Urology, Kawasaki Medical School, 577 Matsushima, Kurashiki-City, , Okayama, 701-0192, Japan.
Tomohito TanakaCenter for Medical Research & Development, Division of Translational Research, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki, Osaka, 569-8686, Japan.
Hidero YoshimotoDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki, Osaka, 569-8686, Japan.
Kentaro MatsuoDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki, Osaka, 569-8686, Japan.
Yoshiro ImaiDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki, Osaka, 569-8686, Japan.
Ryo TanakaDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki, Osaka, 569-8686, Japan.
Mitsuaki IshidaDepartment of Pathology, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki, Osaka, 569-8686, Japan.
Yoshinobu HiroseDepartment of Pathology, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki, Osaka, 569-8686, Japan.
Satoru MotoyamaDepartment of Gastroenterological Surgery, Japanese Red Cross Akita Hospital, 222-1 Naeshirozawa, Saruta, Kamikitade, Akita-City, Akita, Japan.
Sang-Woong LeeDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki, Osaka, 569-8686, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe 1846C > T polymorphism of the C-reactive protein (CRP) gene is associated with an increased risk of lymph node metastasis in various cancers. This study aimed to examine its association with lymph node metastasis in gastric cancer.

methodsA retrospective analysis of the 1846C > T CRP polymorphism was conducted in patients with submucosal (SM) gastric cancer from April 2011 to March 2022. Genotyping was performed using polymerase chain reaction fragment length polymorphisms. Patients were categorized into differentiated and undifferentiated groups and then subdivided into C/C + C/T and T/T genotypes. We assessed correlations between polymorphisms, lymph node metastasis, and lymphatic and venous invasion. Two sub-analyses were conducted in the differentiated gastric cancer group.

resultsAmong 111 patients with SM gastric cancer, 81 had differentiated tumors, whereas 30 had undifferentiated tumors. In the differentiated group, 4.5% of C/C and C/T genotypes and 18.9% of T/T genotypes exhibited lymph node metastasis, with a 95% negative predictive value. Excluding pT1b1 and tumors ≤ 3 cm, lymph node metastasis occurred in 5.3% of C/C and C/T genotypes and 20.6% of T/T genotypes, with a negative predictive value of 94.7%. For cT1bN0 cases, lymph node metastasis was 0% in C/C and C/T genotypes and 15.8% in T/T genotypes, with a negative predictive value of 100%.

conclusionsIn this exploratory study, the 1846C > T CRP polymorphism suggests that patients with differentiated SM gastric cancer carrying the C/C or C/T genotype have reduced risk of lymph node metastasis, potentially minimizing the need for additional surgery after endoscopic submucosal dissection.

Indexed as

C-Reactive ProteinStomach NeoplasmsAdultAgedFemaleGenetic Predisposition to DiseaseGenotypeHumansLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessPolymorphism, Single NucleotideRetrospective StudiesRisk FactorsC-Reactive ProteinC-reactive proteinGastrectomyGastric cancerGenetic polymorphismLymph node metastasis

Identifiers

PMID41023519

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.