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ArticleDocumenta ophthalmologica. Advances in ophthalmology2025

A unilateral presentation of pigmented paravenous chorioretinal atrophy: a case report.

Hadeel Seraj, Shaima K Alharazi, Enas S Magharbil, Hani B Albalawi, Naif M Alali, Moustafa S Magliyah

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Article in Documenta ophthalmologica. Advances in ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Hadeel SerajVitreoretinal Division, King Khaled Eye Specialist Hospital, Al-Oruba Street, PO Box 7191, 11462, Riyadh, Kingdom of Saudi Arabia.
Shaima K AlharaziVitreoretinal Division, King Khaled Eye Specialist Hospital, Al-Oruba Street, PO Box 7191, 11462, Riyadh, Kingdom of Saudi Arabia.
Enas S MagharbilUveitis Department, Jeddah Eye Hospital, Jeddah, Kingdom of Saudi Arabia.
Hani B AlbalawiDivision of Ophthalmology, Department of Surgery, Faculty of Medicine, University of Tabuk, Tabuk, Kingdom of Saudi Arabia.
Naif M AlaliDivision of Ophthalmology, Department of Surgery, Faculty of Medicine, University of Tabuk, Tabuk, Kingdom of Saudi Arabia.
Moustafa S MagliyahVitreoretinal Division, King Khaled Eye Specialist Hospital, Al-Oruba Street, PO Box 7191, 11462, Riyadh, Kingdom of Saudi Arabia. mmagliyah@kkesh.med.sa.ORCID 0000-0001-6350-7464

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis case report aims to describe an atypical presentation of pigmented paravenous chorioretinopathy (PPCRA).

methodsDetailed clinical ophthalmologic examinations, multimodal imaging and electroretinography of a 33-year-old woman who presented with unilateral PPCRA.

resultsA 33-year-old female who is known to have hypothyroidism and had previous bariatric surgery, referred for retinal evaluation following incidental findings during a refractive surgery consultation. Fundus examination revealed unilateral segmental perivascular hyperpigmentation, vascular sclerosis, and areas of chorioretinal atrophy, raising the differential diagnosis of pigmented paravenous chorioretinopathy (PPCRA) versus resolved retinal vasculitis. The patient reported no significant ocular symptoms apart from decreased night vision in one eye and denied a history of acute visual loss or photophobia. Systemic workup, including autoimmune and infectious serologies, imaging, and a detailed clinical history, was unremarkable. The patient reported consanguinity within the family.

conclusionThis report underscores the challenge of distinguishing PPCRA, a rare, typically bilateral hereditary condition, from resolved vasculitis, which often presents unilaterally with a history of systemic inflammation. Fluorescein angiography and optical coherence tomography were instrumental in identifying the lack of active inflammation and vascular leakage, favoring the diagnosis of PPCRA.

Indexed as

Eye Diseases, HereditaryRetinal DegenerationAdultDiagnosis, DifferentialElectroretinographyFemaleFluorescein AngiographyHumansMultimodal ImagingTomography, Optical CoherenceVisual AcuityPigmented paravenous chorioretinal atrophyPPCRARetinal dystrophy, ERGUveitis

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.