Evidence map›Paper›PMID 41023500›Full record

ArticleJournal of neuro-oncology2025

Prognostic value of temporal muscle thickness in pediatric medulloblastoma patients aged 3-12 years.

Xu An, Junhua Wang, Jingzhe Yuan, Xuan Zhou, Xiaozhu Liu, Xiaoyan Sun, Jian Gong, Qingnan Wu, Yunwei Ou

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xu An *Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 Nansihuanxilu, Fengtai District, Beijing, China.
Junhua Wang *Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing, China.
Jingzhe Yuan *Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 Nansihuanxilu, Fengtai District, Beijing, China.
Xuan ZhouDepartment of Anesthesiology, Tsinghua University Yuquan Hospital, Beijing, China.
Xiaozhu LiuDepartment of Critical Care Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Xiaoyan SunThe institute of artificial intelligence, Hefei Comprehensive National Science Center, Anhui, China.
Jian GongDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 Nansihuanxilu, Fengtai District, Beijing, China.
Qingnan WuKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Molecular Oncology, Peking University Cancer Hospital & Institute, Beijing, China. 1049533997@qq.com.
Yunwei OuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 Nansihuanxilu, Fengtai District, Beijing, China. ouyangyunwei@sina.cn.

Funding

The Institute of Artificial Intelligence, Hefei Comprehensive National Science Center 21KT013The National Natural Science Foundation of China 82327806
6 · The paper itself

Abstract

purposeThis retrospective, multicenter cohort study aimed to investigate the prognostic significance of temporal muscle thickness (TMT) in medulloblastoma (MB) patients.

methodsPreoperative cranial MRI was used to measure TMT. Patients were divided into training and test cohorts. An optimal TMT cutoff for progression-free survival (PFS) and overall survival (OS) was established.

resultsAmong the 303 enrolled MB patients, TMT was found to be associated with prognosis in the 230 patients aged 3-12 years. TMT demonstrated positive correlations with age and body mass index, while inverse associations were observed with the presence of hydrocephalus and metastasis. A TMT cutoff value of 6.115 mm was established in the training cohort, which served as a significant threshold for both PFS and OS. The 5-year PFS rates were (38.0 ± 11.5) % (low mean-TMT group) versus (88.3 ± 3.2) % (high mean-TMT group), and OS rates were (57.2 ± 8.7) % versus (96.5 ± 1.7) %, respectively. The multivariate Cox regression revealed significantly better PFS (hazard ratio (HR) = 0.165; 95% confidence interval (CI): 0.064-0.427; P < 0.001) and OS (HR = 0.064; 95% CI: 0.020-0.207; P < 0.001) in patients above versus below this cutoff. These findings were validated in test cohort and two independent validation cohorts.

conclusionMRI-measured TMT is a potential prognostic indicator for MB patients aged 3-12 years, and may help guide risk stratification and treatment planning. To validate its clinical applicability, large-sample prospective researches remain essential.

Indexed as

Cerebellar NeoplasmsMedulloblastomaTemporal MuscleChildChild, PreschoolFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMalePrognosisRetrospective StudiesSurvival RateMedulloblastomaOverall survivalProgression-free survivalSarcopeniaTemporal muscle thickness

Identifiers

PMID41023500

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