Evidence map›Paper›PMID 41023471›Full record

ReviewMolecular biology reports2025

Potential new drug sources for the treatment of Parkinson's disease: flavonoid O-glycosides.

Yehao Wang, Jinjin Yang, Xin Jiang, Runda Yuan, Ruyang Cheng, Ningxia Lu, Ao Gao, Shumin Liu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yehao WangInstitute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Jinjin YangInstitute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Xin JiangInstitute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Runda YuanInstitute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Ruyang ChengInstitute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Ningxia LuInstitute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Ao GaoInstitute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Shumin LiuInstitute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China. keji-liu@163.com.

Funding

National Natural Science Foundation of China 82274125
6 · The paper itself

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. With the increase in the global aging population, the global prevalence of PD has soared, and the burden of global medical resources is increasingly heavy. Although modern medicine has progressed in treating PD, existing drugs still have drawbacks regarding Mechanism and efficacy, intensifying the urgency of developing new drugs. Researchers have favored natural treatments for their safety in recent years and have increasingly become an essential source for developing new drugs. Flavonoid O-glycoside compounds are one of the main active ingredients of natural products and have shown satisfactory efficacy in treating PD, thus becoming potential drugs for treating neurodegenerative diseases. In this study, we systematically evaluated the Mechanism of several specific flavonoid O-glycoside compounds in the treatment of PD, conducted a relatively in-depth summary and discussion of their biological activities, and compared them with other flavonoid O-glycoside compounds. This provides a theoretical basis for further future mechanism research on flavonoid O-glycoside compounds. And lay the foundation and set an example for the development and application of natural products. This review indicates that flavonoid O-glycoside compounds are up-and-coming new therapeutic drugs for Parkinson's disease (PD) and can be used in PD prevention and treatment strategies.

Indexed as

FlavonoidsGlycosidesParkinson DiseaseAnimalsBiological ProductsHumansBiological ProductsFlavonoidsGlycosidesBiological activityFlavonoidsMechanism of actionNatural medicinesO-glycosidesParkinson's disease

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.