SynthesisOral and maxillofacial surgery2025
Head and neck related quality of life following glossectomy among tongue cancer patients: a systematic review and meta-analysis.
Synthesis in Oral and maxillofacial surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Comparative evaluation of non-surgical and surgical treatment modalities for oral cancer.Bioinformation · 2026Article
- Oral cancer and the impact of glossectomy: challenges and pathways to recovery.Frontiers in oral health · 2026Review
- Prognostic Value of Primary Total Glossectomy in Tongue Cancer: A Systematic Review and Meta-Analysis of Survival Outcomes.Diagnostics (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study synthesized previous studies to evaluate the post-operative head and neck-related quality of life (QoL) and pre-post operative change in the QoL of tongue cancer patients who underwent glossectomy.
methodsFollowing the PRISMA guidelines, databases were searched on April 1, 2025, for relevant articles without date limits. Mean estimates and standardized mean differences were calculated for post-glossectomy and pre-post glossectomy changes in QoL, respectively. A random-effects model employing the restricted maximum likelihood was conducted. Effect heterogeneity was assessed using Q and I
resultsA total of 56 studies (2,832 participants; mean [SD] age, 55.1 [7.5] years; 68.2% male) were included in the study. The meta-analysis estimated a pooled composite QoL score of 71.9% (95% CI: 68.3-75.4) following glossectomy. Subgroup analyses revealed that patients who underwent partial/hemi-glossectomy (vs. subtotal/near-total/total glossectomy) and primary closure (vs. flap reconstruction) have higher QoL following tongue resection. Meta-analysis of 18 studies reporting both pre- and post-glossectomy QoL found an overall stabilization in QoL (SMD: -0.22; 95% CI: -0.63 to 0.19).
conclusionThis study provides potential evidence that patients with tongue cancer generally maintain their QoL following glossectomy, particularly in key functional domains such as swallowing, speech, and taste. However, high heterogeneity necessitates cautious interpretation.
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