Evidence map›Paper›PMID 41023241›Full record

ArticleClinical neuroradiology2026

First-line Aspiration Thrombectomy with the RED43 Catheter for Acute Ischemic Stroke due to Medium or Distal Vessel Occlusion.

Vera Aebischer, Alex Brehm, Nikki Rommers, Alejandro Spiotta, Mohammad Sowlat, Karthik Raghuram, Justin M Cappuzzo, Jeffrey Beecher, Charles Matouk, Abdelaziz Amllay and 19 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Vera AebischerDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland. vera.aebischer@usb.ch.ORCID http://orcid.org/0009-0005-1066-9773
Alex BrehmDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.ORCID http://orcid.org/0000-0002-1630-6210
Nikki RommersDepartment of Clinical Research, University of Basel, University Hospital Basel, 4031, Basel, Switzerland.ORCID http://orcid.org/0000-0003-0311-5009
Alejandro SpiottaDepartment of Neurosurgery, Medical University of South Carolina, 29425, Charleston, SC, USA.ORCID http://orcid.org/0000-0002-7142-5538
Mohammad SowlatDepartment of Neurosurgery, Medical University of South Carolina, 29425, Charleston, SC, USA.ORCID http://orcid.org/0000-0001-6777-4332
Karthik RaghuramReno Radiological Associates and University of Nevada, Mill St., 1155, Reno, NV, USA.ORCID http://orcid.org/0000-0003-2995-2913
Justin M CappuzzoEndovascular and Cerebrovascular Neurosurgery, Atlantic Brain and Spine, 28412, Wilmington, NC, USA.ORCID http://orcid.org/0000-0002-5794-3339
Jeffrey BeecherEndovascular and Cerebrovascular Neurosurgery, Atlantic Brain and Spine, 28412, Wilmington, NC, USA.
Charles MatoukDepartment of Neurosurgery, Yale University, 333 Cedar Street, 06510, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-3234-9541
Abdelaziz AmllayDepartment of Neurosurgery, Yale University, 333 Cedar Street, 06510, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-3357-4134
Axel RohrVancouver General Hospital & UBC Hospital, Department of Radiology/Neuroradiology, University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0003-4684-7920
Manraj HeranVancouver General Hospital & UBC Hospital, Department of Radiology/Neuroradiology, University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0003-0040-6054
David VoldersDivision of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-4074-8702
Pascal J MosimannDivision of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-5111-1972
Mohammad Al-TibiDivision of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-3589-2526
Johan WasséliusStroke Imaging Research Group, Department of Clinical Sciences Lund, Lund University and Department of Radiology, Skåne University Hospital, Lund, Sweden.ORCID http://orcid.org/0000-0003-1896-381X
Björn M HansenStroke Imaging Research Group, Department of Clinical Sciences Lund, Lund University and Department of Radiology, Skåne University Hospital, Lund, Sweden.ORCID http://orcid.org/0000-0001-8661-9063
Markus HoltmannspötterDepartment for Diagnostic & Interventional Neuroradiology, Paracelsus Medical University, Breslauer Str. 201, 90471, Nuremberg, Germany.ORCID http://orcid.org/0000-0003-2536-5244
Martin SchlösserDepartment for Diagnostic & Interventional Neuroradiology, Paracelsus Medical University, Breslauer Str. 201, 90471, Nuremberg, Germany.
Stephan MeckelRKH Kliniken Ludwigsburg, Institute of Diagnostic and Interventional Neuroradiology, Posilipostr. 4, 71640, Ludwigsburg, Germany.ORCID http://orcid.org/0000-0001-6468-4526
Oumaima AouaRKH Kliniken Ludwigsburg, Institute of Diagnostic and Interventional Neuroradiology, Posilipostr. 4, 71640, Ludwigsburg, Germany.ORCID http://orcid.org/0009-0006-9717-0779
Suresh GiraganiApollo Hospitals, Hyderabad, Telangana, India.ORCID http://orcid.org/0000-0002-5177-0473
Andrea BoghiS.G. Bosco Hospital, Neuroradiology, Torino, Italy.ORCID http://orcid.org/0000-0003-1729-4036
Nikolaos NtouliasDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.ORCID http://orcid.org/0000-0003-2886-3468
Victor Schulze-ZachauDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.ORCID http://orcid.org/0000-0003-0945-8379
Ioannis TsogkasDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.ORCID http://orcid.org/0000-0003-2561-9603
Kristine A BlackhamDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.ORCID http://orcid.org/0000-0002-1620-1144
Aikaterini AnastasiouDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.ORCID http://orcid.org/0000-0002-5405-4237
Marios PsychogiosDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.ORCID http://orcid.org/0000-0002-0016-414X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTechniques for endovascular thrombectomy in acute ischemic stroke due to medium or distal vessel occlusions (MDVO) need to be improved, and first-line aspiration is emerging as a promising technique. The objective was to describe first-pass and final reperfusion rates with a triaxial direct aspiration first pass technique (ADAPT) and a novel, quadriaxial technique (QUATTRO-ADAPT) using RED43 Reperfusion Catheters to target MDVOs.

methodsThis retrospective study collected data from 11 stroke centers in Europe and North America between 2023 and 2025. Patients with primary, isolated MDVOs who underwent thrombectomy using first-line aspiration with RED43 Reperfusion Catheters were included. Primary outcome was first-pass successful reperfusion rate (modified Treatment In Cerebral Infarction score ≥ 2b). Additionally, final reperfusion rates, complications and functional outcomes up to 90 days were evaluated.

resultsWe included 85 cases. Median age was 74 years (IQR 67-81) and median National Institutes of Health Stroke Scale score 9 (IQR 6-15). The majority (69.4%) had an occlusion of the co- or nondominant M2 segment of the middle cerebral artery. First-pass successful reperfusion was 63.5% overall, with 55.6% for the triaxial ADAPT and 69.4% for the quadriaxial QUATTRO-ADAPT. Final successful reperfusion was achieved in 96.5%. Complications included vessel perforations (2.4%), subarachnoid hemorrhage (3.5%), parenchymal hematoma type 2 (2.4%), and symptomatic intracerebral hemorrhage (1.2%). Functional independence (modified Rankin Scale 0-2) at 90 days was observed in 58.7%.

conclusionThis study shows that first-line aspiration, especially in a quadriaxial approach, can be effective and safe. These findings should be evaluated in prospective trials.

Indexed as

Ischemic StrokeThrombectomyAgedAged, 80 and overCathetersFemaleHumansMaleRetrospective StudiesSuctionTreatment OutcomeAspirationEndovascular thrombectomyFirst-line techniqueMedium or distal vessel occlusionStroke

Identifiers

PMID41023241
PMCPMC13008998

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