Evidence map›Paper›PMID 41023197›Full record

ArticleEMBO molecular medicine2025

Complete attenuation of Plasmodium falciparum sporozoites by atovaquone-proguanil.

Steffen Borrmann, Zita Sulyok, Katja Müller, Rolf Fendel, Mihály Sulyok, Johannes Friesen, Albert Lalremruata, Thaisa Lucas Sandri, The Trong Nguyen, Carlos Lamsfus Calle and 30 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Steffen Borrmann *Institut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany. steffen.borrmann@uni-tuebingen.de.ORCID http://orcid.org/0000-0001-9189-4393
Zita Sulyok *Institut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0009-0007-4311-4509
Katja Müller *Department of Molecular Parasitology, Institute of Biology, Humboldt University, Berlin, Germany.ORCID http://orcid.org/0000-0001-5100-0981
Rolf Fendel *Institut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0003-4716-0311
Mihály SulyokInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.
Johannes FriesenDepartment of Molecular Parasitology, Institute of Biology, Humboldt University, Berlin, Germany.
Albert LalremruataInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0002-4692-7835
Thaisa Lucas SandriInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.
The Trong NguyenInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0002-5433-7712
Carlos Lamsfus CalleInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0002-6766-1765
Annette KnoblichInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.
Stephanie SefriedInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.
Javier IbáñezInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0001-6215-6332
Freia-Raphaella LorenzInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0002-7401-2720
Henri Lynn HeimannInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.
David M WellerInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.
Regina SteuderInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.
Selorme AdukpoInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0003-3173-996X
Patricia Granados BayonInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.
Zsófia MolnárInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.
Meral EsenInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.
Wolfram MetzgerInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.
Eric R JamesSanaria Inc., Rockville, MD, USA.
Adam RubenSanaria Inc., Rockville, MD, USA.
Yonas AbebeSanaria Inc., Rockville, MD, USA.
Sumana ChakravartySanaria Inc., Rockville, MD, USA.
Anita ManojSanaria Inc., Rockville, MD, USA.
Natasha KcProtein Potential LLC, Rockville, MD, USA.
Tooba MurshedkarSanaria Inc., Rockville, MD, USA.
Julius C R HafallaDepartment of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.ORCID http://orcid.org/0000-0002-5452-9263
Tamirat Gebru WoldearegaiInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0001-9508-1787
Fiona O'RourkeInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.
Jana HeldInstitut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.
Pete BillingsleySanaria Inc., Rockville, MD, USA.ORCID http://orcid.org/0000-0003-1142-4813
B Kim Lee SimSanaria Inc., Rockville, MD, USA.ORCID http://orcid.org/0000-0002-8598-8905
Thomas L RichieSanaria Inc., Rockville, MD, USA.ORCID http://orcid.org/0000-0002-2946-5456
Stephen L Hoffman *Sanaria Inc., Rockville, MD, USA.
Peter G Kremsner *Institut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.
Kai Matuschewski *Department of Molecular Parasitology, Institute of Biology, Humboldt University, Berlin, Germany.ORCID http://orcid.org/0000-0001-6147-8591
Benjamin Mordmüller *Institut für Tropenmedizin, Eberhard Karls University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0001-9101-2768

Funding

Plasmodium Falciparum Whole Sporozoite Malaria VaccineR44AI055229 · NIAID · SANARIA, INC. · PI HOFFMAN, STEPHEN LEV · 2005 to 2015
$10.0M
Universal Attenuated Sporozoite Vaccine and Challenge SystemR44AI058375 · NIAID · SANARIA, INC. · PI HOFFMAN, STEPHEN LEV · 2006 to 2018
$9.9M
Angewandte Klinische Forschung 346-0-0Deutsche Forschungsgemeinschaft (DFG) BO 2494/3-2Deutsche Forschungsgemeinschaft (DFG) BO 2494/7-1Deutsche Forschungsgemeinschaft (DFG) SFB544Deutscher Akademischer Austauschdienst (DAAD) 57592740Deutsches Zentrum für Infektionsforschung (DZIF) TTU 03.905Deutsches Zentrum für Infektionsforschung (DZIF) TTU 03.913EC | H2020 | ERA-LEARN | European and Developing Countries Clinical Trials Partnership (EDCTP) 101145698NIAID NIH HHS R44 AI055229NIAID NIH HHS R44 AI058375Small Business Innovation Research (SBIR) 2R44AI058375Small Business Innovation Research (SBIR) 5R44AI055229
6 · The paper itself

Abstract

To develop a Plasmodium falciparum (Pf) vaccine that precludes replication inside the host for improved vaccine safety, we tested chemo-attenuation (CVac) of sporozoites (SPZ) with atovaquone-proguanil (AP). In mice, P. berghei sporozoites administered with AP invaded hepatocytes, arrested early, and induced robust protection, which correlated with parasite-specific effector-memory CD8+ T cell responses. In a clinical trial of PfSPZ-CVac (AP), in which three doses of 5.12 × 10

Indexed as

AntimalarialsAtovaquoneMalaria, FalciparumMalaria VaccinesPlasmodium falciparumProguanilSporozoitesAnimalsAntibodies, ProtozoanCD8-Positive T-LymphocytesDrug CombinationsFemaleHumansMiceVaccines, AttenuatedAntibodies, ProtozoanAntimalarialsAtovaquoneatovaquone, proguanil drug combinationDrug CombinationsMalaria VaccinesProguanilVaccines, AttenuatedAtovaquone–proguanilChemo-attenuationControlled Human Malaria InfectionMalaria VaccinePlasmodium falciparum

Identifiers

PMID41023197
PMCPMC12602697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.