Evidence map›Paper›PMID 41023114›Full record

ArticleScientific reports2025

Change in platelet and leukocyte counts and hospital mortality in adults with acute kidney injury receiving continuous renal replacement therapy.

Lan N Bui, Joshua W Lambert, Chloe G Braun, Lucas J Liu, Augusto X Cama-Olivares, Victor Ortiz-Soriano, Tomonori Takeuchi, Orson W Moe, Robert D Toto, Ashita J Tolwani and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lan N BuiPalm Beach Atlantic University Gregory School of Pharmacy, 901 S Flagler Drive, West Palm Beach, FL, 33401, USA.
Joshua W LambertUniversity of Cincinnati College of Nursing, 3110 Vine Street, Cincinnati, OH, 45221, USA.
Chloe G BraunDepartment of Pediatric Critical Care, University of Alabama at Birmingham, 1600 7th Avenue South, Suite 102, 35233, Birmingham, AL, USA.
Lucas J LiuDepartment of Computer Science, Division of Biomedical Informatics, Department of Internal Medicine, University of Kentucky, University of Kentucky, Davis Marksbury Building 329 Rose Street, Lexington, KY, 40506, USA.
Augusto X Cama-OlivaresDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, ZRB 638 1720 2nd Avenue South, 35294, Birmingham, AL, USA.
Victor Ortiz-SorianoInternal Medicine, Brookwood Baptist Health, 2010 Brookwood Medical Center Drive, Birmingham, Birmingham, Alabama, AL, 35209, USA.
Tomonori TakeuchiDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, ZRB 638 1720 2nd Avenue South, 35294, Birmingham, AL, USA.
Orson W MoeDepartments of Internal Medicine and Physiology Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.
Robert D TotoDepartment of Internal Medicine, Center for Translational Research, Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.
Ashita J TolwaniDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, ZRB 638 1720 2nd Avenue South, 35294, Birmingham, AL, USA.
Jin ChenDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, ZRB 638 1720 2nd Avenue South, 35294, Birmingham, AL, USA.
Kianoush KashaniDivision of Nephrology and Hypertension, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester 200 First St. SW, 55905, Rochester, MN, USA.
Javier A NeyraDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, ZRB 638 1720 2nd Avenue South, 35294, Birmingham, AL, USA. jneyra@uabmc.edu.

Funding

Artificial Intelligence to Predict Outcomes in Patients with Acute Kidney Injury on Continuous Renal Replacement TherapyR01DK133539 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Girish Nitin Nadkarni, Javier A. Neyra · 2023 to 2026
$2.6M
NCATS NIH HHS R01DK133539
6 · The paper itself

Abstract

backgroundChanges in platelet and white blood cell (WBC) counts during CRRT could identify patients at risk for adverse outcomes. We examined the association of change in platelet and WBC from pre-CRRT to during-CRRT with hospital mortality.

methodsThis multicenter, retrospective cohort study included 1,413 adults with AKI requiring CRRT at two tertiary medical centers (2011-2021). Platelet and WBC change from pre- to during CRRT were assessed as a percentage and categorized by standard deviation (SD). Multivariable LASSO regression and interaction analyses investigated associations with hospital mortality.

resultsA > 1 SD platelet count drop during CRRT was independently associated with hospital mortality (aOR: 1.82, 95% CI: 1.06, 3.13). A > 1 SD WBC count increase during CRRT did not significantly increase mortality (aOR 1.41, 95% CI: 0.88, 2.29). Interaction analyses revealed four sub-groups associated with increased mortality: pre-CRRT low platelet count that remained low, pre-CRRT normal platelet count that decreased, pre-CRRT elevated WBC count that remained high, and normal or elevated pre-CRRT WBC count that increased.

interpretationIn critically ill adults, a drop in platelets after CRRT initiation was associated with increased hospital mortality. Monitoring platelet and WBC during CRRT in reference to pre-CRRT levels could help identify high-risk patients.

Indexed as

Acute Kidney InjuryBlood PlateletsContinuous Renal Replacement TherapyHospital MortalityAdultAgedFemaleHumansLeukocyte CountMaleMiddle AgedPlatelet CountRetrospective StudiesAcute kidney injuryAKIContinuous renal replacement therapyCRRTLeukocytesPlatelets

Identifiers

PMID41023114
PMCPMC12480951

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.