ArticleScientific reports2025
A case study on optimizing helical tomotherapy parameters for small cell lung cancer with extensive pleural metastasis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- A simulation study of a novel spiral volumetric modulated arc therapy for enhanced dose delivery efficiency and quality in radiotherapy.Medical physics · 2026Article
- Gantry-period-guided modulation factor selection in helical tomotherapy: effects on delivery efficiency, dosimetry and verification accuracy.Frontiers in oncology · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
The study aimed to evaluate the impact of various parameters on treatment plan quality and delivery time in helical tomotherapy (HT) for small cell lung cancer patients with extensive pleura metastasis (SCLC-EPM) and to identify the optimal parameter combination. Four SLCL-EPM patients were included. For each patient, the planning target volume (PTV) and organs at risk (OARs), including the left lung, right lung, total lung, heart, esophagus, spinal cord, were delineated. A total of 27 treatment plans per patient (108 total) were generated by varying three parameters: Field Width (FW), Pitch Factor (PF), Modulation Factor (MF). FW defined treatment field length at isocenter. Smaller FWs boosted precision but extend beam-on time. PF was couch movement per rotation relative to FW; tighter PFs reduced dose fluctuations; MF, the max-to-average leaf-opening ratio, improved modulation at the cost of longer delivery. The reference plan used default values (FW = 2.5 cm, PF = 0.287, MF = 3.6), assumed to yield the best dose distribution and treatment time. Plan quality was assessed using PTV metrics (Homogeneity index (HI), conformity index (CI), D
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