ArticleScientific reports2025
Elucidation of the treatment mechanism of pulsed radiofrequency based on its antiinflammatory effects.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Predictors of Treatment Success Following Pulsed Radiofrequency of the Lumbar Dorsal Root Ganglion: A Multivariable Prediction Model with Clinical Nomogram.Current pain and headache reports · 2026Review
- Pulsed Radiofrequency for Post-Stroke Complications: From Neuromodulation to Functional Recovery.Current neurology and neuroscience reports · 2026Review
- Transcutaneous Pulsed Radiofrequency in Chronic Pain: A Systematic Review of Randomized Controlled Trials.Pain and therapy · 2026Review
- Peripheral Neuropathy: A Phenotype-Driven Review for Diagnosis and Management.Revista de neurologia · 2026Review
- Effects of Esketamine Infusion by Patient-Controlled Intravenous Analgesia in Patients With Zoster-Associated Pain: A Retrospective Study.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Response to "Methodological and Mechanistic Considerations on Duration-Dependent Pulsed Radiofrequency for Rheumatoid Arthritis" [Response to Letter].Journal of pain research · 2026Article
- The effects of pulsed radiofrequency stimulation on mitochondrial function in neurons: a mini review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Effect of Pulsed Radiofrequency with Various Time-Course on Rheumatoid Arthritis Joint Pain in Rats.Journal of pain research · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Pulsed radiofrequency (PRF) is recognized as an effective pain relief for treating chronic pain, though the mechanism of the analgesic effect remains unclear. Recent studies have focused on the potential anti-inflammatory effect in analgesia through PRF. Therefore, we investigated the anti-inflammatory effects of PRF using the knee pain mouse models induced by monoiodoacetic acid. Our findings demonstrated that PRF on the sciatic nerve significantly reduces knee pain, synovitis, and inflammatory cytokines, thereby supporting the hypothesis that PRF exerts an anti-inflammatory effect. Moreover, a tracer study and western blotting analysis revealed that PRF inhibited axonal transport in small dorsal root ganglion (DRG) neurons in the spinal cord and suppressed the secretion of calcitonin gene-related peptide (CGRP) and substance P (SP), both of which are associated with persistent inflammation, into the knee joint. Finally, the administration of both CGRP and SP agonists to the knee joint nullified the analgesic and anti-inflammatory effects of PRF. In conclusion, our studies revealed that PRF exerted analgesic effects based on anti-inflammatory effects through inhibition of CGRP and SP secretion caused by impaired axonal transport in small DRG neurons. We hope that these findings will lead to further dissemination of PRF treatment in the future.
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Registered trials
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