Evidence map›Paper›PMID 41023007›Full record

ArticleScientific reports2025

Repurposing resveratrol for redox-mediated inhibition of MTH1 in breast cancer.

Aaliya Taiyab, Arunabh Choudhury, Shaista Haider, Aanchal Rathi, Afzal Hussain, Mohamed F Alajmi, Anindita Chakrabarty, Faez Iqbal Khan, Anas Shamsi, Md Imtaiyaz Hassan

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aaliya TaiyabCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India.
Arunabh ChoudhuryCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India.
Shaista HaiderDepartment of Life Sciences, School of Natural Sciences, Shiv Nadar Institution of Eminence Deemed to be University, NH91, Tehsil Dadri, Gautam Buddha Nagar, Uttar Pradesh, 201314, India.
Aanchal RathiDepartment of Biotechnology, Faculty of Life Sciences, Jamia Millia Islamia, New Delhi, 110025, India.
Afzal HussainDepartment of Pharmacognosy, College of Pharmacy, King Saud University, 2457, Riyadh, 11451, Saudi Arabia.
Mohamed F AlajmiDepartment of Pharmacognosy, College of Pharmacy, King Saud University, 2457, Riyadh, 11451, Saudi Arabia.
Anindita ChakrabartyDepartment of Life Sciences, School of Natural Sciences, Shiv Nadar Institution of Eminence Deemed to be University, NH91, Tehsil Dadri, Gautam Buddha Nagar, Uttar Pradesh, 201314, India.
Faez Iqbal KhanDepartment of Biological Sciences, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, China.
Anas ShamsiCentre of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates. anas.shamsi18@gmail.com.
Md Imtaiyaz HassanCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India. mihassan@jmi.ac.in.

Funding

King Saud University ORF-2025-122Ministry of Education, India F.No.4l-1l2018-TS-1
6 · The paper itself

Abstract

The increased metabolic activity in cancer cells often leads to higher levels of reactive oxygen species compared to normal cells, which can cause damage to cellular components, including DNA. Cancer cells rely on MTH1 to maintain their DNA integrity and cellular function to counteract this damage. MTH1 is critical in sanitizing oxidized nucleotide pools by removing damaged nucleotides. Inhibition of MTH1 disrupts this repair process, leading to increased DNA damage and cell death in cancer cells. In this study, we present resveratrol (RV) as a potential MTH1 inhibitor. Docking and MD Simulations illustrated the effective binding of RV to the active site of the MTH1 protein, forming a notably stable complex. The fluorescence binding studies estimated a high binding affinity of RV with MTH1 (K

Indexed as

Breast NeoplasmsDNA Repair EnzymesDrug RepositioningPhosphoric Monoester HydrolasesResveratrolApoptosisCell ProliferationFemaleHumansMCF-7 CellsMolecular Docking SimulationMolecular Dynamics SimulationOxidation-ReductionOxidative StressReactive Oxygen Species8-oxodGTPaseDNA Repair EnzymesPhosphoric Monoester HydrolasesReactive Oxygen SpeciesResveratrolCancer therapyDrug discoveryMD simulationsMTH1 proteinNatural productsResveratrol

Identifiers

PMID41023007
PMCPMC12480932

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.