ArticleScientific reports2025
Sugemalimab plus chemotherapy versus chemotherapy for advanced gastric cancer in China: a cost-effectiveness analysis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Camrelizumab plus CAPOX versus CAPOX for HER2-negative gastric or gastro-oesophageal junction adenocarcinoma: a cost-effectiveness analysis.Frontiers in pharmacology · 2026Article
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Authors and funding
3 authors.
Funding
Abstract
This study aimed to evaluate the cost-effectiveness of sugemalimab plus chemotherapy compared to chemotherapy in the treatment of advanced gastric cancer in China. A Markov model of partitioned survival was developed based on the GEMSTONE-303 Phase III clinical trial evaluating sugemalimab in combination with chemotherapy for advanced gastric cancer. The model incorporates three distinct health states: progression-free survival, disease progression, and death.The transition probabilities between these states and drug treatment and adverse reaction datas were derived from the clinical trial.Direct medical costs were obtained from local sources, and utility values were derived from published literature. Costs and outcomes were projected over a lifetime horizon and discounted at an annual rate of 5%. Quality-adjusted life years (QALY) were utilized as a measure of health outcomes, with the incremental cost-effectiveness ratio (ICER) serving as the principal economic assessment parameter. The threshold for willingness to pay (WTP) was set at $40,343.68 USD per QALY. Sensitivity analysis was conducted to assess the robustness and reliability of the model. The base-case analysis revealed that the ICER for sugemalimab plus chemotherapy compared to chemotherapy alone was $80,573.50 per QALY for patients with programmed death-ligand 1 (PD-L1) combined positive score (CPS) ≥ 5, and $64,428.81 per QALY gained for those with PD-L1 CPS ≥ 10. Both ICERs exceeded the willingness-to-pay (WTP) threshold of $40,343.68 per QALY.Probabilistic sensitivity analysis demonstrated that the probability of sugemalimab plus chemotherapy being cost-effective at the WTP threshold was 0% and 1.5% for the PD-L1 CPS ≥ 5 and CPS ≥ 10 subgroups, respectively.Sensitivity analyses showed that the results were robust to parameter variations. The findings suggest that sugemalimab plus chemotherapy was not a cost-effective treatment option for advanced gastric cancer compared to chemotherapy alone in China.
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