Evidence map›Paper›PMID 41022972›Full record

ArticleScientific reports2025

Clinical significance of Ureaplasma species in bronchopulmonary dysplasia development in preterm infants.

Hafiz Muhammad Sohail Sarwar, Qingfei Hao, Jing Zhang, Yanna Du, Haoming Chen, Mohammed Awadh Abdun, Jing Chen, Jing Li, Xiuyong Cheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hafiz Muhammad Sohail SarwarDepartment of Neonatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Qingfei HaoDepartment of Neonatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Jing ZhangDepartment of Neonatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Yanna DuDepartment of Neonatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Haoming ChenDepartment of Neonatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Mohammed Awadh AbdunDepartment of Internal Medicine, People's Hospital of Zhengzhou University and Henan Provincial People's Hospital, Zhengzhou, 450003, Henan, China.
Jing ChenDepartment of Neonatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Jing LiDepartment of Neonatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Xiuyong ChengDepartment of Neonatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China. fccchengxy@zzu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This prospective study aimed to investigate colonization of Ureaplasma spp. in preterm infants to evaluate the relationship between Ureaplasma spp. colonization and BPD including other neonatal morbidities. A cohort of 357 preterm infants was examined for Ureaplasma spp. detection. Samples as nasopharyngeal swabs and gastric aspirates (non-intubated infants) whereas tracheal aspirates (intubated infants), were collected within 24 h of birth from infants with < 37 weeks gestational age (GA). Each sample was tested with culture and real-time polymerase chain reaction (RT-PCR) to confirm Ureaplasma spp. colonization. A total of 12 (3.3%) preterm infants (GA, 30.5 ± 2.2 weeks, P = 0.001; BW, 1,529 ± 501 g, P = 0.005) were positive for Ureaplasma spp. colonization. 23 (6.8%) preterm infants (GA, 28.7 ± 1.1 weeks, P = 0.001; BW, 1,234 ± 441 g, P = 0.005) developed BPD. Ureaplasma spp. colonization and BPD development showed an inverse relation with GA and birth weight (BW), and were associated with one antenatal factor (premature rupture of membranes; PROM), two natal factors (smaller GA, lower BW), one postnatal factor (longer use of supplemental oxygen), and p-value was significant for all factors (P < 0.05). Incidence of BPD in Ureaplasma spp. positive group was higher than in Ureaplasma spp. negative group (n = 3, 25% vs. n = 20, 6%, P = 0.001). Multivariate logistic regression analysis revealed a common correlation of Ureaplasma spp. colonization and BPD development with smaller GA (P = 0.012 & 0.001; 95%CI: 0.590-0.937 & 0.181-0.627), independent correlation of Ureaplasma spp. colonization with PROM (P = 0.002; 95%CI: 2.226-35.547) whereas independent correlation of BPD development with Ureaplasma spp. colonization (P = 0.037; 95%CI: 1.167-123.809) and more ventilator days (P = 0.003; 95%CI: 1.197-2.486). Ureaplasma spp. colonization is associated with PROM, smaller GA, and higher incidence of BPD. All preterm infants delivered by mothers with PROM and/or with smaller GAs should be investigated for Ureaplasma spp. colonization to anticipate BPD incidence.

Indexed as

Bronchopulmonary DysplasiaUreaplasmaUreaplasma InfectionsBirth WeightClinical RelevanceFemaleGestational AgeHumansInfant, NewbornInfant, PrematureMaleProspective StudiesBronchopulmonary dysplasiaNeonatal morbiditiesPreterm infantsRisk factorsUreaplasma species colonization

Identifiers

PMID41022972
PMCPMC12480627

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.