Evidence map›Paper›PMID 41022893›Full record

ArticleScientific reports2025

IL6/STAT3 induced GRWD1 mediates aerobic glycolysis via P53/GLUT1 signal axis in colon carcinoma.

Jin Shang, Hong-Yue Ren, Fa-Hui Liu, Dong-Hua Liu, Shi-Hang Tang, Guo-Xian Guan, Guo-Qiang Su, Dong-Yan Shen, Xin Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jin ShangCancer Research Center, School of Medicine, Xiamen University, 4221 Xiang'an South Road, Xiamen, 361102, Fujian Province, China.
Hong-Yue RenBasic Medical College, Zhangzhou Health Vocational College, Zhangzhou, 363000, Fujian Province, China.
Fa-Hui LiuXiamen Cell Therapy Research Center, The First Affiliated Hospital of Xiamen University School of Medicine, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Xiamen, 361003, Fujian Province, China.
Dong-Hua LiuXiamen Cell Therapy Research Center, The First Affiliated Hospital of Xiamen University School of Medicine, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Xiamen, 361003, Fujian Province, China.
Shi-Hang TangXiamen Cell Therapy Research Center, The First Affiliated Hospital of Xiamen University School of Medicine, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Xiamen, 361003, Fujian Province, China.
Guo-Xian GuanDepartment of Colorectal Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, People's Republic of China.
Guo-Qiang SuDepartment of Colorectal Tumor Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Xiamen, 361003, Fujian Province, China. suguoqiang@xmu.edu.cn.
Dong-Yan ShenXiamen Cell Therapy Research Center, The First Affiliated Hospital of Xiamen University School of Medicine, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Xiamen, 361003, Fujian Province, China. shendongyan@163.com.
Xin ZhouDepartment of Colorectal Tumor Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Xiamen, 361003, Fujian Province, China. 1012256893@qq.com.

Funding

the National Natural Science Foundation of China 82270664the Natural Science Foundation of Fujian Province, China 2023J01250the Project of Xiamen Cell Therapy Research Center, Xiamen, China 3502Z20214001
6 · The paper itself

Abstract

GRWD1, a novel WD40-repeat-containing protein designated glutamate-rich WD repeat, is highly expressed in CRC and participates in a series of oncogenic activities. However, the cause of GRWD1 overexpression and its oncogenic mechanism in CRC remains elusive. This study revealed that GRWD1 was correlated with inflammation and was progressively upregulated during the progression of Azoxymethane/Dextran sodium sulfate (AOM/DSS) in a mouse model. Moreover, GRWD1 was activated by the IL-6/STAT3 signal pathway in CRC cells. Besides, it promoted the degradation of p53 and further induced GLUT1 to facilitate aerobic glycolysis in CRC. Taken together, GRWD1 played an oncogenic role in tumorigenesis of CRC and represented a promising therapeutic target.

Indexed as

Colonic NeoplasmsGlucose Transporter Type 1GlycolysisInterleukin-6STAT3 Transcription FactorTumor Suppressor Protein p53AnimalsAzoxymethaneCell Line, TumorDextran SulfateDisease Models, AnimalGene Expression Regulation, NeoplasticHumansMaleMiceSignal TransductionAzoxymethaneDextran SulfateGlucose Transporter Type 1Interleukin-6Slc2a1 protein, mouseSTAT3 protein, humanSTAT3 Transcription FactorTumor Suppressor Protein p53Aerobic glycolysisColon carcinomaGLUT1GRWD1IL-6/STAT3

Identifiers

PMID41022893
PMCPMC12480064

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.