Evidence map›Paper›PMID 41022886›Full record

ArticleScientific reports2025

Spontaneous calcium transients in hair cell stereocilia.

Saman Hussain, Miloslav Sedlacek, Runjia Cui, Wendy Zhang-Hooks, Dwight E Bergles, Jung-Bum Shin, Katie S Kindt, Bechara Kachar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Spontaneous Calcium Signalling in the Developing Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Saman Hussain *Laboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 35 A Convent Drive, Room 3D824, Bethesda, MD, 20892, USA. saman.samanhussain@gmail.com.
Miloslav Sedlacek *Laboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 35 A Convent Drive, Room 3D824, Bethesda, MD, 20892, USA.
Runjia CuiLaboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 35 A Convent Drive, Room 3D824, Bethesda, MD, 20892, USA.
Wendy Zhang-HooksThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Dwight E BerglesThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Jung-Bum ShinDepartment of Neuroscience, University of Virginia, Charlottesville, VA, 22908, USA.
Katie S KindtLaboratory of Cellular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, 20892, USA.
Bechara KacharLaboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 35 A Convent Drive, Room 3D824, Bethesda, MD, 20892, USA. kacharb@nidcd.nih.gov.

Funding

In vivo investigation of sensory hair cell function and developmentZIADC000085 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI KINDT, KATIE · 2014 to 2025
$21.4M
Spontaneous activity in the developing cochleaR01DC008860 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI DWIGHT E BERGLES · 2008 to 2026
$7.1M
MOLECULAR BASIS OF TRANSDUCTION IN AUDITORY SENSORY ORGANSZ01DC000002 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI KACHAR, BECHARA · 1989 to 2008
$3.9M
Intramural NIH HHS Z01 DC000002Intramural NIH HHS ZIA DC000085National Institute on Deafness and Other Communication Disorders (NIDCD) Intramural Research Program 1ZIADC000085-01National Institute on Deafness and Other Communication Disorders (NIDCD) Intramural Research Program Z01-DC000002NIDCD NIH HHS R01 DC008860
6 · The paper itself

Abstract

The hair bundle of auditory and vestibular hair cells converts mechanical stimuli into electrical signals through mechanoelectrical transduction (MET). The MET apparatus is built around a tip link that connects neighboring stereocilia that are aligned in the direction of mechanosensitivity of the hair bundle. Upon stimulation, the MET channel complex responds to changes in tip-link tension and allows a cation influx into the cell. Ca

Indexed as

CalciumCalcium SignalingHair Cells, AuditoryStereociliaAnimalsHair Cells, VestibularMechanotransduction, CellularMiceZebrafishCalcium

Identifiers

PMID41022886
PMCPMC12480455

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.