Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Maria BlumenkrantzColumbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, NY, 10032, USA.ORCID http://orcid.org/0000-0002-4140-033X
Felicia WoronColumbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, NY, 10032, USA.ORCID http://orcid.org/0009-0001-4940-9072
Ernesto GagarinColumbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, NY, 10032, USA.ORCID http://orcid.org/0009-0004-3839-7098
Everett WeinsteinColumbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, NY, 10032, USA.
Maryam H KamelColumbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, NY, 10032, USA.ORCID http://orcid.org/0009-0009-7346-5371
Leonardo CamposDepartment of Orthopedic Surgery, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, NY, 10032, USA.ORCID http://orcid.org/0009-0007-8485-2022
Agnieszka GerasDepartment of Statistics, Irving Institute for Cancer Dynamics, Columbia University, New York, NY, 10027, USA.
Troy AndersonColumbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, NY, 10032, USA.
Julia MoColumbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, NY, 10032, USA.ORCID http://orcid.org/0000-0002-1234-8966
Desmarie SherwoodColumbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, NY, 10032, USA.
Maya GwinColumbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, NY, 10032, USA.
Bianca DumitrascuDepartment of Statistics, Irving Institute for Cancer Dynamics, Columbia University, New York, NY, 10027, USA.ORCID http://orcid.org/0000-0001-8328-2354
Nadeen O ChahineDepartment of Orthopedic Surgery, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, NY, 10032, USA.ORCID http://orcid.org/0000-0002-0478-6042
Joanna SmeetonColumbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, NY, 10032, USA. jms2504@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-6126-2560
Funding
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
PREDOCTORAL TRAINING GRANT IN HUMAN GENETICS &DEVELOPMET32GM007088 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SHEN, MICHAEL M. · 1985 to 2020
$7.1M
Training in Cellular, Molecular and Biomedical Studies (CMBS)T32GM145766 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Rebecca Anne Haeusler, RONALD K. LIEM · 2022 to 2026
$4.1M
Anti-inflammatory Cell Based Repair of Intervertebral Disc DegenerationR01AR077760 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHAHINE, NADEEN O. · 2021 to 2025
$3.1M
Deciphering multi-scale differentiation and patterning cues driving whole craniofacial joint regenerationDP2DE032725 · NIDCR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SMEETON, JOANNA MARJORIE · 2022 to 2025
$2.5M
Sustained Delivery of RhoA activator for Treatment of Intervertebral Disc DegenerationR21AR080516 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BAJPAYEE, AMBIKA GOEL, CHAHINE, NADEEN O. · 2022 to 2023
$508k
ECM remodeling and crosstalk with cell fate in zebrafish ligament regenerationF31DE033220 · NIDCR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MO, JULIA · 2023 to 2025
$149k
Transcriptional regulation of progenitor cell fate in craniofacial ligament regenerationF31DE031970 · NIDCR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ANDERSON, TROY · 2022 to 2024
Adult mammalian synovial joints have limited regenerative capacity, where injuries heal with mechanically inferior fibrotic tissues. Here we developed a unilateral whole-joint resection model in adult zebrafish to advance our understanding of how to stimulate regrowth of native synovial joint tissues. Using a combination of microCT, histological, live imaging, and single-cell RNA sequencing (scRNAseq) approaches after complete removal of all joint tissues, we find de novo regeneration of articular cartilage, ligament, and synovium into a functional joint. Clonal lineage tracing and scRNAseq implicate a multipotent, neural crest-derived population in the adult skeleton as a cell source for these regenerating tissues. Together, our findings reveal latent molecular and cellular programs within the adult skeleton that are deployed to regenerate a complex joint with lubricated articular cartilage.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Dynamic cell fate plasticity and tissue reintegration drive functional adult synovial joint regeneration after complete resection. · full record | OpenQuestion