ArticleNature communications2025
The pericardium forms as a distinct structure during heart formation.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Spatial transcriptomics reveals coordinated ventricular patterning and maturation in the developing human heart.Nature communications · 2026Article
- Multimodal optical imaging for the assessment of the teratogenic effects of ethanol on zebrafish development.Journal of biomedical optics · 2026Article
- Age-dependent Transcriptional Programs Distinguish Pediatric from Adult Dilated Cardiomyopathy.medRxiv : the preprint server for health sciences · 2026Article
- Contemporary Review of Clinical Features, Multi-Modality Imaging, and Management of Pericardial Cysts.Journal of clinical medicine · 2026Review
- Hedgehog and Bmp signaling pathways play opposing roles during establishment of the cardiac inflow tract in zebrafish.Development (Cambridge, England) · 2026Article
- Lineage labeling with zebrafish hand2 Cre and CreERT2 recombinase CRISPR knock-ins.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Early coordination of cell migration and cardiac fate determination during mammalian gastrulation.The EMBO journal · 2025Article
- Lineage labeling with zebrafishbioRxiv : the preprint server for biology · 2024Article
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Abstract
The heart is formed from diverse cell lineages that assemble into a functional unit, including the pericardium, a mesothelial sac that supports movement, homeostasis, and immune responses. However, its developmental origins remain unresolved. Here, we find the pericardium forms within the lateral plate mesoderm from dedicated mesothelial progenitors that are distinct from the classic heart field. Imaging of transgenic zebrafish reporters documents lateral plate mesoderm cells that emerge lateral of the heart field among a continuous mesothelial progenitor band. Single-cell transcriptomics and trajectories of hand2-expressing lateral plate mesoderm reveal distinct populations of mesothelial precursors, including pericardial precursors. Their mesothelial gene expression signature is conserved in mammals and carries over to post-natal development. Light sheet imaging and machine learning-supported cell tracking documents the migration of pericardial precursors from the edge of the heart field to form the pericardial cavity. Genetic perturbations reveal this process occurs independently of heart formation, with canonical Wnt/β-catenin signaling modulating pericardial cell number and tissue rigidity. We connect the pathological expression of secreted Wnt antagonists of the SFRP family found in pediatric dilated cardiomyopathy to increased pericardial stiffness in neonatal rats. Altogether, our data integrate pericardium formation as an independent process into heart morphogenesis.
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