ArticleNature communications2025
A basic framework to explain splice-site choice in eukaryotes.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Loss of cellular RNA homeostasis contributes to MDA5 activation during virus infection.Nature immunology · 2026Article
- Article
- Simple sequence repeats and their expansions: role in plant development, environmental response and adaptation.The New phytologist · 2025Review
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Authors and funding
18 authors.
Funding
Abstract
Changes in splicing can mediate phenotypic variation, ranging from flowering time differences in plants to genetic diseases in humans. Splicing changes occur due to differences in splice-site strength, often influenced by genetic variation and the environment. How genetic variation influences splice-site strength remains poorly understood, largely because splice-site usage across transcriptomes has not been empirically quantified. Here, we quantify the use of individual splice-sites in Arabidopsis, Drosophila and humans and treat these measurements as molecular phenotypes to map variation in splice-site usage through GWAS. We carry out more than 130,000 GWAS with splice-site usage phenotypes, cataloguing genetic variation associated with changes in the usage of individual splice-sites across transcriptomes. We find that most of the common, genetically controlled variation in splicing is cis and there are no major trans hotspots in the three species analyzed. We group splice-sites based on GT[N]
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