Evidence map›Paper›PMID 41022728›Full record

ArticleNature communications2025

HIV vaccine candidate ΔV1gp120 formulated in ALFQA adjuvant augments mucosal immunity in female macaques.

Massimiliano Bissa, Mohammad Arif Rahman, Luca Schifanella, Katherine C Goldfarbmuren, Isabela Silva de Castro, Emmanuel K Woode, Anna Gutowska, Melvin N Doster, Sophia Brown, Sarkis Sarkis and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Massimiliano Bissa *Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA. massimiliano.bissa@nih.gov.ORCID http://orcid.org/0000-0003-3455-3992
Mohammad Arif Rahman *Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-6120-8943
Luca Schifanella *Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
Katherine C Goldfarbmuren *Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID http://orcid.org/0000-0001-8774-7454
Isabela Silva de Castro *Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
Emmanuel K WoodeAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
Anna GutowskaAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-9873-6432
Melvin N DosterAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
Sophia BrownAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
Sarkis SarkisAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-4355-6338
Neil R KanchettyAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
Cynthia A Pise-MasisonAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
Robyn Washington-ParksAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
Katherine McKinnonCCR Building 41 Flow Cytometry Core, National Cancer Institute, Bethesda, MD, USA.
Shraddha BasuU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Jiae KimU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.ORCID http://orcid.org/0000-0003-2900-1667
Ryan AlvingOak Ridge Institute of Science and Education, Oak Ridge, TN, USA.
Dominic Paquin-ProulxU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.ORCID http://orcid.org/0000-0003-1407-3414
Kombo F N'guessanU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Xiaoying ShenDepartment of Surgery, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0002-8387-3952
David C MontefioriDepartment of Surgery, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0003-0856-6319
Timothy CardozoNew York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA.ORCID http://orcid.org/0000-0002-0643-4497
Gary R MatyasU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.ORCID http://orcid.org/0000-0002-2074-2373
Mangala RaoU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Genoveffa FranchiniAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA. franchig@mail.nih.gov.ORCID http://orcid.org/0000-0003-2851-6589

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Simian or Human immunodeficiency virus (SIV or HIV) vaccines based on V1-deleted envelope virus-like particles, delivered by the DNA/ALVAC platforms, followed by the ΔV1gp120 boost formulated in Alum, protect 50% and 80% of macaques from mucosal infection with SIV

Indexed as

Adjuvants, ImmunologicAIDS VaccinesHIV InfectionsImmunity, MucosalSimian Acquired Immunodeficiency SyndromeAlum CompoundsAnimalsAntibody-Dependent Cell CytotoxicityFemaleHumansMacaca mulattaMacrophagesSAIDS VaccinesSimian Immunodeficiency VirusAdjuvants, ImmunologicAIDS VaccinesAlum CompoundsSAIDS Vaccines

Identifiers

PMID41022728
PMCPMC12480912

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.