Evidence map›Paper›PMID 41022693›Full record

ArticleTranslational psychiatry2025

Neurometabolic predictors of mental effort in the frontal cortex.

Arthur Barakat, Jules Brochard, Mathias Pessiglione, Jean-Philippe Godin, Bernard Cuenoud, Lijing Xin, Nicolas Clairis, Carmen Sandi

Abstract read
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Arthur BarakatLaboratory of Behavioral Genetics (LGC), Brain Mind Institute (BMI), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Jules BrochardTransdisciplinary Research Areas, Life and Health, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-8781-1644
Mathias PessiglioneMotivation, Brain and Behavior team, Paris Brain Institute, Sorbonne University, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Paris, France.ORCID http://orcid.org/0000-0002-6992-3677
Jean-Philippe GodinNestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-4630-9543
Bernard CuenoudNestlé Health Science, Epalinges, Switzerland.ORCID http://orcid.org/0000-0001-5120-1740
Lijing XinCIBM Center for Biomedical Imaging, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-5450-6109
Nicolas ClairisLaboratory of Behavioral Genetics (LGC), Brain Mind Institute (BMI), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. nicolas.clairis@protonmail.com.ORCID http://orcid.org/0000-0001-6777-7429
Carmen SandiLaboratory of Behavioral Genetics (LGC), Brain Mind Institute (BMI), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. carmen.sandi@epfl.ch.ORCID http://orcid.org/0000-0001-7713-8321

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 10531C_ 212914Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) CRSII5_183564
6 · The paper itself

Abstract

Motivation drives individuals to overcome costs to achieve desired outcomes, such as rewards or avoidance of punishment, with significant variability across individuals. The dorsomedial prefrontal cortex/dorsal anterior cingulate cortex (dmPFC/dACC) and anterior insula are key brain regions implicated in effort-based decision-making. Here, we utilized proton magnetic resonance spectroscopy (

Indexed as

Decision MakingGyrus CinguliInsular CortexMotivationPrefrontal CortexAdultAspartic AcidFemaleGlutamic AcidHumansLactic AcidMachine LearningMagnetic Resonance ImagingMaleProton Magnetic Resonance SpectroscopyYoung AdultAspartic AcidGlutamic AcidLactic Acid

Identifiers

PMID41022693
PMCPMC12479776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.