Evidence map›Paper›PMID 41022687›Full record

ArticleNature communications2025

GM-CSF-dependent CD301b

Christina L Wilkinson, Keiko Nakano, Sara A Grimm, Gregory S Whitehead, Yukitomo Arao, Perry J Blackshear, Peer W Karmaus, Michael B Fessler, Donald N Cook, Hideki Nakano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Christina L WilkinsonImmunity, Inflammation and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Keiko NakanoImmunity, Inflammation and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0003-2735-4119
Sara A GrimmIntegrative Bioinformatics Support Group, Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0003-3050-1909
Gregory S WhiteheadImmunity, Inflammation and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Yukitomo AraoSignal Transduction Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Perry J BlackshearSignal Transduction Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0002-9561-8529
Peer W KarmausImmunity, Inflammation and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Michael B FesslerImmunity, Inflammation and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0002-8262-8613
Donald N CookImmunity, Inflammation and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA. cookd@niehs.nih.gov.ORCID http://orcid.org/0000-0002-0052-3755
Hideki NakanoImmunity, Inflammation and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA. nakanoh@niehs.nih.gov.ORCID http://orcid.org/0000-0002-6343-4709

Funding

Allergic sensitization through the airwayZIAES102025 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI COOK, DONALD N · 2009 to 2025
$32.6M
Intramural NIH HHS ZIA ES102025U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) ZIA ES102025-09
6 · The paper itself

Abstract

The severity of allergic asthma is driven by the balance between allergen-specific T regulatory (Treg) and T helper (Th)2 cells. However, it is unclear whether specific subsets of conventional dendritic cells (cDCs) promote the differentiation of Tregs. We have identified a subset of lung resident type 2 cDCs (cDC2s) that display high levels of CD301b and have potent Treg-inducing activity ex vivo. Single-cell RNA sequencing and adoptive transfer experiments show that during allergic sensitization, many CD301b

Indexed as

AllergensDendritic CellsGranulocyte-Macrophage Colony-Stimulating FactorImmune ToleranceLungAdoptive TransferAnimalsAsthmaCell DifferentiationFemaleMiceMice, Inbred BALB CMice, Inbred C57BLTh2 CellsT-Lymphocytes, RegulatoryAllergensGranulocyte-Macrophage Colony-Stimulating Factor

Identifiers

PMID41022687
PMCPMC12480895

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.