Evidence map›Paper›PMID 41022681›Full record

ReviewAdvances in biological regulation2026

Conventional and alternative approaches for targeting PIK3CA and PTEN alterations in head and neck, breast, and other cancers.

Jovanka Gencel-Augusto, Jennifer R Grandis, Daniel E Johnson

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in biological regulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jovanka Gencel-AugustoDepartment of Otolaryngology, Head and Neck Surgery, University of California San Francisco, San Francisco, CA, USA.
Jennifer R GrandisDepartment of Otolaryngology, Head and Neck Surgery, University of California San Francisco, San Francisco, CA, USA.
Daniel E JohnsonDepartment of Otolaryngology, Head and Neck Surgery, University of California San Francisco, San Francisco, CA, USA. Electronic address: Daniel.Johnson@ucsf.edu.

Funding

Integrating genomics and the protein interactome for HPV+ head and neck cancer therapyR35CA231998 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2018 to 2024
$6.2M
PI3K Pathway Mutations in Head and Neck CancerR01DE023685 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRANDIS, JENNIFER RUBIN, JOHNSON, DANIEL E · 2014 to 2023
$5.1M
NCI NIH HHS R35 CA231998NIDCR NIH HHS R01 DE023685
6 · The paper itself

Abstract

Genetic alterations in genes encoding components of the PI3K/AKT/mTOR signaling pathway are frequently observed in head and neck squamous cell carcinoma (HNSCC), breast cancer, and a variety of other human malignancies. In particular, PIK3CA, encoding the p110α catalytic subunit of PI3K enzyme, is altered in approximately 30 % of HNSCC tumors and 37 % of breast cancer tumors. In addition, loss of PTEN protein, a negative regulator of PI3K signaling, occurs in roughly one-third of HNSCC. Here, we review the impact of these alterations on the growth and metabolism of cancer cells and summarize progress that has been made in the development and clinical evaluation of inhibitors that directly target p110α and related proteins. We also describe emerging approaches that are identifying unique vulnerabilities and targeting opportunities in tumors characterized by PIK3CA or PTEN alterations.

Indexed as

Breast NeoplasmsCarcinoma, Squamous CellHead and Neck NeoplasmsPhosphatidylinositol 3-KinasesPTEN PhosphohydrolaseAnimalsClass I Phosphatidylinositol 3-KinasesFemaleHumansMolecular Targeted TherapySignal TransductionClass I Phosphatidylinositol 3-KinasesPhosphatidylinositol 3-KinasesPIK3CA protein, humanPTEN PhosphohydrolasePTEN protein, humanAlpelisibBreast cancerCowden syndromeHead and neck cancerMetabolismp110alphaPIK3CAPTENSREBP1/2

Identifiers

PMID41022681
PMCPMC12916096

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.