ArticleRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)2025
Immediate and sustained effects of acupuncture on the default mode network.
Article in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed.
- LR3-LI4 needling side and configuration are associated with phase-specific cortical activation and network organization: a functional near-infrared spectroscopy study in healthy adults.Frontiers in neurology · 2026Trial
- Restoration of Excitation-Inhibition Balance and Improvement of Schizophrenia-like Behavioral Deficits via Electroacupuncture.CNS neuroscience & therapeutics · 2026Article
- Precision acupuncture for chemotherapy-induced peripheral neuropathy: multitarget mechanisms and integrated clinical translation framework.Frontiers in neurology · 2026Review
- Cerebral blood flow and functional connectivity immediate changes following intradermal acupuncture in major depressive disorder.Frontiers in neuroscience · 2026Article
- Neurobiological mechanisms of acupuncture for post-ischemic stroke comorbid insomnia and cognitive impairment: a narrative review.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo investigate, using functional magnetic resonance imaging (fMRI) techniques, the immediate and sustained effects of acupuncture on functional connectivity (FC) within the default mode network (DMN) and external FC.
methodsThirty healthy participants received acupuncture needle stimulation at Baihui (GV20) and Yintang (GV29) and underwent resting-state fMRI scans in three phases: pre-needle insertion, during needle retention, and post-needle removal. Each phase lasted 20 minutes.
resultsIn terms of within-network connectivity of the DMN, post-needle removal scans showed a decrease in FC between the medial prefrontal cortex (mPFC) and the angular gyrus (ANG) compared to pre-needle insertion scans. The FC analysis from seed points to whole-brain voxels showed the following changes: compared to pre-needle insertion scans, acupuncture needle insertion increased the FC between the posterior cingulate cortex/precuneus (PCC/PCU) and Cerebellum_8_L; acupuncture needle withdrawal increased the FC between the PCC/PCU and Cerebellum_8_L; acupuncture needle insertion decreased the FC between ANG and Frontal_Sup_Medial_L; and acupuncture needle withdrawal decreased the FC between ANG and Frontal_Sup_Medial_L.
conclusionThese results suggested that acupuncture has an impact on the DMN and that these effects are sustained, not just immediate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.