Evidence map›Paper›PMID 41022546›Full record

ArticleJournal of endourology2026

Electromotive Drug Administration in the Porcine Ureter: First

Bruce M Gao, Yi Xi Wu, Seyed Hossein H Sharifi, Seyed Amiryaghoub M Lavasani, Seyedamirvala Saadat, Mark Sarwat Hana, Victor Pham, Erika Martinez-Carcamo, Olga Derbeneva, Aymon Ali and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of endourology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Bruce M GaoDepartment of Urology, University of California, Irvine, Orange, California, USA.
Yi Xi WuDepartment of Urology, University of California, Irvine, Orange, California, USA.
Seyed Hossein H SharifiDesai Sethi Urology Institution, University of Miami, Miami, Florida, USA.
Seyed Amiryaghoub M LavasaniDepartment of Urology, University of California, Irvine, Orange, California, USA.ORCID 0009-0007-8143-0158
Seyedamirvala SaadatDepartment of Urology, University of California, Irvine, Orange, California, USA.
Mark Sarwat HanaDepartment of Urology, University of California, Irvine, Orange, California, USA.
Victor PhamDepartment of Urology, University of California, Irvine, Orange, California, USA.
Erika Martinez-CarcamoDepartment of Urology, University of California, Irvine, Orange, California, USA.
Olga DerbenevaDepartment of Urology, University of California, Irvine, Orange, California, USA.
Aymon AliDepartment of Urology, University of California, Irvine, Orange, California, USA.
Zachary E TanoDepartment of Urology, University of California, Irvine, Orange, California, USA.
Pengbo JiangDepartment of Urology, University of California, Irvine, Orange, California, USA.
Roshan M PatelDepartment of Urology, University of California, Irvine, Orange, California, USA.
Jaime LandmanDepartment of Urology, University of California, Irvine, Orange, California, USA.
Ralph V ClaymanDepartment of Urology, University of California, Irvine, Orange, California, USA.

Funding

Institute for Clinical and Translational ScienceUM1TR004927 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAN M COOPER, Eric J. Vilain · 2024 to 2026
$12.2M
NCATS NIH HHS UM1 TR004927
6 · The paper itself

Abstract

objectiveRetrograde intrarenal surgery is limited by the narrow caliber of the human ureter, resulting in both reluctance to deploy larger ureteral access sheaths and, at times, failed primary ureteral access, requiring placement of a ureteral stent and a delayed second procedure. In this study, we sought to evaluate the application of electromotive drug administration (EMDA) to deliver smooth muscle relaxants to the porcine ureter to facilitate acute ureteral dilation.

methodsEighteen juvenile female Yorkshire pigs were randomized into three treatment groups (alfuzosin, aminophylline, or isoproterenol;

resultsOnly alfuzosin with EMDA increased ureteral size compared with NS alone (alfuzosin

conclusionIn this first report, EMDA-mediated

Indexed as

DilatationUreterAminophyllineAnimalsFemaleIsoproterenolQuinazolinesSus scrofaSwinealfuzosinAminophyllineIsoproterenolQuinazolineselectromotive drug administrationforce sensorsurgical injuryureteral access sheathsureteral dilationureteroscopy

Identifiers

PMID41022546
PMCPMC13055499

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.