Evidence map›Paper›PMID 41022535›Full record

Observational studyOpen heart2025

Intravenous thrombolysis before percutaneous coronary intervention in patients with non-ST-elevation acute coronary syndrome and acute ischaemic stroke: a subanalysis of the PRAISE study.

Annahita Sedghi, Regina von Rennenberg, Gabor Petzold, Georg Nickenig, Bernd Kallmünzer, Stephan Achenbach, Roman Huber, Julia Seeger, Bettina von Sarnowski, Goetz Thomalla and 18 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Open heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Annahita SedghiDepartment of Neurology, Medical Faculty and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.
Regina von RennenbergDepartment of Neurology with Experimental Neurology and Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Gabor PetzoldDepartment for Neurology, Section of Vascular Neurology, Universitätsklinikum Bonn, Bonn, Germany.
Georg NickenigDepartment of Cardiology, Universitätsklinikum Bonn, Bonn, Germany.
Bernd KallmünzerDepartment of Neurology, University Hospital Erlangen, Erlangen, Germany.
Stephan AchenbachMedizinische Klinik 2, University Hospital Erlangen, Erlangen, Germany.
Roman HuberDepartment of Neurology, Medical Campus Lake Constance, Friedrichshafen, Germany.
Julia SeegerDepartment of Cardiology and Intensive Care, Medical Campus Lake Constance, Friedrichshafen, Germany.
Bettina von SarnowskiDepartment of Neurology, University Medicine Greifswald, Greifswald, Germany.
Goetz ThomallaDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Peter Arthur RinglebDepartment of Neurology, University Hospital Heidelberg, Heidelberg, Germany.
Dominik MichalskiDepartment of Neurology, Leipzig University Hospital, Leipzig, Germany.
Ulrich LaufsDepartment of Cardiology, Leipzig University Hospital, Leipzig, Germany.
Georg RoylNeurovascular Center, Department of Neurology, University Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Kristina SzaboDepartment of Neurology, Mannheim Center for Translational Neuroscience, Medical Faculty Mannheim, Mannheim, Germany.
Norman MangnerDepartment of Internal Medicine and Cardiology, Heart Center Dresden, Medical Faculty and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.
Volker PuetzDepartment of Neurology, Medical Faculty and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.
Lars KellertDepartment of Neurology, LMU University Hospital, Munich, Germany.
Stefan KaeaebDepartment of Cardiology, LMU University Hospital, Munich, Germany.
Silke WunderlichDepartment of Neurology, Klinikum Rechts der Isar, School of Medicine and Health, Technical University of Munich, Munich, Germany.
Karl-Ludwig LaugwitzDepartment of Internal Medicine I, TUM University Hospital, Technical University of Munich, Munich, Germany.
Martina PetersenDepartment of Neurology, Klinikum Osnabrück GmbH, Osnabrück, Germany.
Annerose MengelDepartment of Neurology and Stroke, Eberhard-Karls University of Tübingen, Tübingen, Germany.
David M LeistnerDepartment of Cardiology, Goethe University Frankfurt, Frankfurt, Germany.
Ulf LandmesserDepartment of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Matthias EndresKlinik und Hochschulambulanz für Neurologie, Charite - Universitatsmedizin Berlin, Berlin, Germany.
Christian H Nolte *Department of Neurology with Experimental Neurology and Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Timo Siepmann *Department of Neurology, Medical Faculty and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany timo.siepmann@ukdd.de.ORCID http://orcid.org/0000-0003-2196-5904

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn patients with acute ischaemic stroke (AIS) and concomitant non-ST-elevation acute coronary syndrome (NSTE-ACS), the role of intravenous thrombolysis (IVT) before percutaneous coronary intervention (PCI) is unclear.

methodsWe performed a subanalysis of the PRAISE (PRediction of Acute coronary syndrome in acute Ischemic StrokE) study, a multicentre, prospective observational study in 247 patients with AIS and elevated high-sensitivity cardiac troponin who underwent coronary angiography based on European Society of Cardiology guidelines. The impact of IVT prior to PCI on coronary artery flow (Thrombolysis in Myocardial Infarction (TIMI) score) and myocardial perfusion (TIMI myocardial perfusion score) was compared using Fisher's exact test and logistic regression analysis, adjusting for time from stroke onset to PCI.

resultsAmong 71 patients with AIS undergoing PCI, those who received IVT prior to PCI for NSTE-ACS (33 women; median age 77 (66-82 IQR)) achieved a TIMI grade 3 flow more frequently than those undergoing direct PCI (97% vs 79%; p=0.04). Regression analysis indicated a trend toward improved coronary artery flow with IVT (adjusted OR 8.5, 95% CI 0.9 to 75.3; p=0.05). Myocardial perfusion did not differ between groups (p=0.06).

conclusionsThis subanalysis suggests that IVT before PCI may enhance coronary artery flow in selected patients with NSTE-ACS with AIS. The results of this exploratory subanalysis warrant further investigation, particularly in patients with delayed access to PCI.

Indexed as

Acute Coronary SyndromeFibrinolytic AgentsIschemic StrokePercutaneous Coronary InterventionThrombolytic TherapyAdministration, IntravenousAgedAged, 80 and overCoronary AngiographyCoronary CirculationFemaleHumansMaleProspective StudiesTime FactorsTreatment OutcomeFibrinolytic AgentsAcute Coronary SyndromeAtherosclerosisPercutaneous Coronary InterventionPharmacology, ClinicalStroke

Identifiers

PMID41022535
PMCPMC12481274

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.