Evidence map›Paper›PMID 41022534›Full record

ArticleOpen heart2025

Outpatient heart failure specialist care following acute heart failure hospitalisation improves long-term outcomes.

Jonathan Raby, Hesham Aggour, Manju George, Hannah Glatzel, Benjamin Fidock, Molly Winter, Karmen Quek, Saul Federman, Josephine Chaplin, Mari Kononen and 8 more

Abstract read
In one paragraph

Article in Open heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jonathan RabyCardiology, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe, Buckinghamshire, UK.ORCID http://orcid.org/0000-0002-2313-0479
Hesham AggourCardiology, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe, Buckinghamshire, UK.
Manju GeorgeCardiology, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe, Buckinghamshire, UK.
Hannah GlatzelCardiology, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe, Buckinghamshire, UK.
Benjamin FidockCardiology, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe, Buckinghamshire, UK.
Molly WinterCardiology, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe, Buckinghamshire, UK.
Karmen QuekCardiology, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe, Buckinghamshire, UK.
Saul FedermanCardiology, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe, Buckinghamshire, UK.
Josephine ChaplinCardiology, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe, Buckinghamshire, UK.
Mari KononenCardiology, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe, Buckinghamshire, UK.
Nicola BowersCardiology, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe, Buckinghamshire, UK.
Andrew Money-KyrleCardiology, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe, Buckinghamshire, UK.
Norman QureshiCardiology, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe, Buckinghamshire, UK.
Rodney De PalmaCardiology, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe, Buckinghamshire, UK.
Soroosh FiroozanCardiology, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe, Buckinghamshire, UK.
Punit RamrakhaCardiology, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe, Buckinghamshire, UK.
Piers CliffordCardiology, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe, Buckinghamshire, UK.
Mayooran ShanmuganathanCardiology, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe, Buckinghamshire, UK mayooran.shan@cardiov.ox.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHospitalisation with acute heart failure (AHF) carries a high risk of death, and those surviving to discharge remain at high risk of death or rehospitalisation with AHF. The impact of outpatient heart failure (HF) specialist care after discharge from AHF hospitalisation on longer-term outcomes is unclear in contemporary UK practice.

methodsA retrospective analysis of a cohort of 2104 patients admitted to hospital due to AHF between 2014-2022 in a single UK county was performed. Patient characteristics, left ventricular ejection fraction (EF) (LVEF) category (HF with reduced EF (LVEF ≤40%; HFrEF), HF with mildy reduced EF (LVEF 41%-49%; HFmrEF) and HF with preserved EF (LVEF ≥50%; HFpEF)) and survival free from a composite end point of AHF rehospitalisation or death are described. Cox regression survival analysis was performed to explore the impact of baseline patient characteristics and HF specialist care on long-term outcomes.

resultsThe median age of the cohort was 83 years. HFrEF was present in 36%, HFmrEF in 9% and HFpEF in 55%. 13% died during index AHF hospitalisation. Median follow-up for those surviving to discharge was 618 (IQR 264-1275) days. 21% were rehospitalised due to AHF, and 63% died during follow-up. On adjusted survival analysis of 1511 patients with echocardiogram data available, HF specialist care after discharge from hospital was independently associated with a significant reduction in the composite end point across all LVEF categories (HFrEF: HR 0.577, 95% CI 0.429 to 0.775, p<0.001; HFmrEF: HR 0.485, 0.281-0.834, p=0.009; HFpEF HR 0.762, 0.623-0.931, p=0.008).

conclusionsHF specialist care after discharge for patients hospitalised with AHF is associated with a significant reduction in the long-term risk of rehospitalisation and all-cause death. This association was present across the three LVEF categories (HFrEF, HFmrEF and HFpEF) and was independent of age and important comorbidities.

Indexed as

Ambulatory CareHeart FailureHospitalizationAcute DiseaseAgedAged, 80 and overFemaleFollow-Up StudiesHumansMalePatient ReadmissionRetrospective StudiesRisk FactorsStroke VolumeSurvival RateTime FactorsEchocardiographyEpidemiologyHEART FAILURE

Identifiers

PMID41022534
PMCPMC12481318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.