ArticleJournal of breast cancer2025
Factors Predicting Additional Residual Nodal Disease With a Metastatic Sentinel Node Biopsy or Targeted Axillary Dissection After Neoadjuvant Chemotherapy.
Article in Journal of breast cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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22 authors.
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Abstract
purposeThis study aimed to investigate whether specific clinicopathological characteristics are associated with a lower likelihood of additional positive nodes (APNs) on completion axillary lymph node dissection (cALND).
methodsA total of 497 patients with cT1-4/N1-3 disease underwent cALND following a positive sentinel lymph node biopsy (SLNB) or targeted axillary dissection (TAD) after neoadjuvant chemotherapy (NAC). The APN rate was assessed based on findings from the cALND.
resultsThe median age was 47 (21-84). The overall APN rate was 67.6%. Patients with cT1-2 disease, a breast pathological complete response, removal of > two nodes via SLNB or TAD, only one metastatic node identified at SLNB or TAD, a lymph node ratio (LNR) < 50%, or low-volume metastatic disease (including isolated tumor cells [ITCs] or micro-metastases) at SLNB or TAD were significantly less likely to have APN on cALND (
conclusionIn patients with a positive SLNB or TAD after NAC, an APN rate < 30% on cALND can be achieved in certain subgroups with favorable features, including cT1-2 and cN1 disease and low-volume metastatic burden.
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