ArticleAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2026
Associations between body weight, asthma burden, and type 2 inflammation among under-resourced children.
Article in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Social support network and family resilience among parents of school-age children with asthma: a cross-sectional study of current status and influencing factors.BMC pulmonary medicine · 2026Article
- Inflammatory Dysregulation, Asthma, and Obesity in Children: What is the Relationship?Journal of inflammation research · 2026Review
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Authors and funding
18 authors.
Funding
Abstract
backgroundOverweight/obesity is a risk factor for asthma, particularly in under-resourced children, and contributes to higher disease burden. Type 2 (T2) inflammation, a key characteristic of asthma endotypes, has been inconsistently associated with burden of obesity-related asthma, which may be due to limited overlap between different T2 features, including elevated total serum IgE level, eosinophilia, and allergen sensitization.
objectiveTo investigate the effects of different T2 features on association of overweight/obesity with asthma burden in under-resourced children.
methodsAmong 2160 children aged 6 to 20 years from 4 Inner-City Asthma Consortium cohorts, the association of overweight/obesity with asthma burden (unscheduled visits, hospitalizations, exacerbations, asthma control, and pulmonary function) and the effect of T2 features (total IgE level higher than age-specific cutoffs, total eosinophils > 300 cells/µL, or sensitization to ≥2 allergens) on the association were investigated.
resultsThe odds (odds ratio [95% CI]) of unscheduled visits were higher among those with overweight/obesity (1.35 [1.04-1.75]) and allergen sensitization (1.35 [1.02-1.80]), hospitalizations were higher among those with elevated total IgE level (2.17 [1.27-3.69]) and eosinophilia (2.80 [1.56-5.21]), and poor asthma control was higher among those with elevated total IgE level (1.27 [1.09-1.41]). Overweight/obesity and all T2 features were associated with lower forced expiratory volume in 1 second/forced vital capacity ratio. There was no synergistic or clinically significant mediating influence of any of T2 features on the association of overweight/obesity with asthma burden.
conclusionAmong under-resourced children with asthma, overweight/obesity and T2 inflammation are largely independently associated with unscheduled visits and pulmonary function deficits. T2 inflammation, but not overweight/obesity, is associated with poor control and hospitalizations.
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