Evidence map›Paper›PMID 41021886›Full record

ArticleRedox report : communications in free radical research2025

FOXO1-NMNAT3 axis dysregulation promotes doxorubicin cardiotoxicity: NAD

Fang Cheng, Minzhu Zhao, Qi Wang, Hongli Xiong, Kai Yu, Chong Chen, Ying Zhu, Yemiao Chen, Jianbo Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox report : communications in free radical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fang ChengBiobank, Chongqing Public Health Medical Center, Chongqing, People's Republic of China.
Minzhu ZhaoDepartment of Forensic Medicine, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, People's Republic of China.
Qi WangDepartment of Forensic Medicine, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, People's Republic of China.
Hongli XiongDepartment of Forensic Medicine, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, People's Republic of China.
Kai YuDepartment of Forensic Medicine, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, People's Republic of China.
Chong ChenDepartment of Forensic Medicine, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, People's Republic of China.
Ying ZhuDepartment of Forensic Medicine, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, People's Republic of China.
Yemiao ChenBiobank, Chongqing Public Health Medical Center, Chongqing, People's Republic of China.
Jianbo LiDepartment of Forensic Medicine, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDoxorubicin (DOX) induces dose-dependent cardiotoxicity, primarily through oxidative stress and metabolic dysregulation. Although NAD

methodsHuman cardiomyocytes (AC16), mouse atrial myocytes (HL-1), and C57BL/6 mice were used to establish the DIC model. The role and mechanism of NAD

resultsUsing integrated

conclusionThis study establishes the dysregulation of the FOXO1-NMNAT3 axis as a key mechanism underlying NAD

Indexed as

AntioxidantsCardiotoxicityDoxorubicinForkhead Box Protein O1NADNicotinamide-Nucleotide AdenylyltransferaseAnimalsCell LineCell SurvivalMaleMiceMice, Inbred C57BLOxidation-ReductionOxidative StressAntioxidantsDoxorubicinForkhead Box Protein O1Foxo1 protein, mouseNADnicotinamide mononucleotide adenylyltransferase 3, mouseNicotinamide-Nucleotide AdenylyltransferasecardiotoxicityCD38Doxorubicinforkhead box protein O1nicotinamide adenine dinucleotidenicotinamide mononucleotide adenylyltransferase 3nuclear factor erythroid-2-related factor 2oxidative stress

Identifiers

PMID41021886
PMCPMC12481541

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.