ArticleSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)2025
Effect of Application of Ultrafine Water Droplets on Water Content in the Stratum Corneum Layer in Excised Human Skin and on Barrier Function in a Three-Dimensional Cultured Human Skin Model.
Article in Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Efficacy of nano-sized ultrafine water clusters in reducing erythema following fractionated picosecond alexandrite laser treatment: a split-face, randomized, evaluator-blinded pilot study.Lasers in medical science · 2026Trial
- Effect of Application of Ultrafine Water Droplets on Water Content in the Stratum Corneum Layer in Excised Human Skin and on Barrier Function in a Three-Dimensional Cultured Human Skin Model.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSkincare using facial humidifiers is gaining attention and has become more popular in Japan as a beauty treatment. A novel type of face humidifier capable of generating ultrafine water droplets has been developed recently. MATERIALS AND
methodsThe change in distribution of sprayed ultrafine water droplets in the stratum corneum of excised human skin over the application period was investigated using confocal Raman microscopy. In addition, changes in trans-epidermal water loss (TEWL) value were evaluated after treatment with ultrafine water droplets using a three-dimensional cultured human skin model (3D skin model). Furthermore, the effect of gene expression related to ceramide production in the skin and ceramide production were also evaluated using a 3D skin model by real-time PCR and high-performance thin-layer chromatography, respectively.
resultsA higher water content at the surface of the skin was confirmed over 45 min after the application. Furthermore, the TEWL value after the application of ultrafine water droplets was sharply decreased. Increased gene expression related to ceramide production was confirmed compared with the application of purified water, and increased levels of ceramide NS were observed.
conclusionThese results suggested that the application of ultrafine water droplets on the skin surface may be useful to maintain a physiologically good skin barrier condition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.