ArticleProceedings of the National Academy of Sciences of the United States of America2025
Tyrosine phosphorylation coupling of one-carbon metabolism and virulence in an endogenous pathogen.
Kendall S Stocke, Satya D Pandey, Shunying Jin, John D Perpich, Lan Yakoumatos, Hirotaka Kosaki, Daniel W Wilkey, Zackary R Fitzsimonds, Aruna Vashishta, Ian Snider and 9 more
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
19 authors.
Kendall S StockeDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY 40202.ORCID 0000-0002-0822-1188 Satya D PandeyDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY 40202.ORCID 0000-0002-4923-1913 Shunying JinDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY 40202.
John D PerpichDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY 40202.ORCID 0000-0002-7884-9202 Lan YakoumatosDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY 40202.
Hirotaka KosakiDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY 40202.ORCID 0009-0009-6444-8043 Daniel W WilkeyDivision of Nephrology and Hypertension, Department of Medicine, University of Louisville, Louisville, KY 40202.ORCID 0000-0001-7491-7696 Zackary R FitzsimondsDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY 40202.
Aruna VashishtaDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY 40202.
Ian SniderDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY 40202.
Mukesh K SriwastvaDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY 40202.
Hong LiJames Graham Brown Cancer Center, College of Medicine, University of Louisville, Louisville, KY 40202.
Jiu-Zhen JinDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY 40202.
Daniel P MillerDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY 40202.ORCID 0000-0002-1332-5870 Michael L MerchantDivision of Nephrology and Hypertension, Department of Medicine, University of Louisville, Louisville, KY 40202.ORCID 0000-0003-4128-4057 Juhi BagaitkarCenter for Microbe and Immunity Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205.ORCID 0000-0001-6185-1915 Silvia M UriarteDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY 40202.ORCID 0000-0002-6171-0271 Jan PotempaDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY 40202.ORCID 0000-0002-3600-7461 Richard J LamontDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY 40202.ORCID 0000-0002-3147-5039 Funding
Understanding the Host-Microbiome-Therapeutic Triad: Implications for Designing Alternative IntravaginalP20GM125504 · NIGMS · UNIVERSITY OF LOUISVILLE · PI James Tristan Collins · 2018 to 2026
$24.4MThe role of ECM-mediated mechanosignaling on regional immunosuppression in GBMP20GM135004 · NIGMS · UNIVERSITY OF LOUISVILLE · PI JUN YAN · 2020 to 2026
$21.1MUniversity of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Amanda Jo LeBlanc · 2020 to 2026
$10.0MMOLECULAR ASPECTS OF ORAL PLAQUE FORMATIONR01DE012505 · NIDCR · UNIVERSITY OF WASHINGTON · PI Richard J Lamont, JAN S POTEMPA · 1998 to 2026
$9.5MP GINGIVALIS INTERACTIONS WITH GINGIVAL EPITHELIAL CELLSR01DE011111 · NIDCR · UNIVERSITY OF WASHINGTON · PI HARIBABU BODDULURI, Richard J Lamont · 1995 to 2026
$5.4MP.gingivalis Interactions with Gingival Epithelial CellsR37DE011111 · NIDCR · UNIVERSITY OF LOUISVILLE · PI LAMONT, RICHARD J · 2009 to 2018
$3.6MFolate-Modulated Virulence of Porphyromonas gingivalisF32DE031493 · NIDCR · UNIVERSITY OF LOUISVILLE · PI STOCKE, KENDALL · 2021 to 2023
$208kPhosphotyrosine Signaling of Porphyromonas gingivalisF32DE026939 · NIDCR · UNIVERSITY OF LOUISVILLE · PI MILLER, DANIEL PATRICK · 2017 to 2018
$96kHHS | NIH | National Institute of Dental and Craniofacial Research (NIDR) DE012505NIDCR NIH HHS F32 DE026939NIDCR NIH HHS F32 DE031493NIDCR NIH HHS R01 DE011111NIDCR NIH HHS R01 DE012505NIDCR NIH HHS R37 DE011111NIEHS NIH HHS P30 ES030283NIGMS NIH HHS P20 GM125504NIGMS NIH HHS P20 GM135004
6 · The paper itselfAbstract
Endogenous pathogens can constrain virulence to ensure survival in the host. Pathogenic state can be controlled by metabolic responses to the prevailing microenvironment; however, the coupling and effector mechanisms are not well understood. Flux through the one-carbon metabolism (OCM) pathway can modulate virulence of the oral pathobiont
Indexed as
CarbonPorphyromonas gingivalisTyrosineAdhesins, BacterialAnimalsFocal Adhesion Kinase 1Gingipain Cysteine EndopeptidasesHumansMicePhosphorylationVirulenceAdhesins, BacterialCarbonFocal Adhesion Kinase 1Gingipain Cysteine EndopeptidasesTyrosineBY kinaseone-carbon metabolismpathogenesisproteolytic enzymes
Identifiers
PMID41021815
PMCPMC12519173
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